Abstract
Background and Objectives: Belimumab (BEL) is a monoclonal antibody approved for the treatment of active systemic lupus erythematosus (SLE) but not for lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE). We aimed to assess BEL's effects on these severe, potentially life-threatening manifestations. Methods: Retrospective observational cohort study using routine clinical data in a case series of patients with SLE receiving BEL. Results: Sixteen patients received BEL therapy for active SLE. Nine were excluded because they had no LN or NPSLE. Six suffered from LN, and one patient had NPSLE. All LN patients received BEL in addition to standard therapy including glucocorticoids, hydroxychloroquine, and mycophenolate mofetil in five cases, and tacrolimus in one case. Three patients with proteinuria >1,000 mg/g creatinine responded well (one complete, two partial renal responses); all other patients had decreasing proteinuria and a reduction in anti-dsDNA levels. The patient with NPSLE who had failed previous therapies had persistent clinical improvement of cutaneous and neuropsychiatric manifestations. There was one mild allergic reaction and one lower respiratory tract infection, but no other adverse event...Continue Reading
References
Nov 14, 2000·Archives of Internal Medicine·M M Ward
Apr 11, 2009·Annals of the Rheumatic Diseases·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics (SLICC)
Oct 23, 2010·Seminars in Arthritis and Rheumatism·Avraham UntermanGisele Zandman-Goddard
Feb 8, 2011·Lancet·Sandra V NavarraUNKNOWN BLISS-52 Study Group
Dec 1, 2011·Arthritis and Rheumatism·Richard FurieUNKNOWN BLISS-76 Study Group
Dec 25, 2012·Lupus·M A DooleyUNKNOWN BLISS-52 and -76 Study Groups
Sep 10, 2013·Lupus·E E FließerS A Patschan
Apr 3, 2014·Scandinavian Journal of Rheumatology·C Sjöwall, L Cöster
Sep 11, 2014·Rheumatology·Tineke KraaijY K Onno Teng
Apr 8, 2015·Annals of Hematology·Federico SimonettaCarlo Chizzolini
Sep 6, 2015·Rheumatology·John G HanlyVernon Farewell
Dec 3, 2015·Lupus Science & Medicine·Farah TamirouDaniel Abramowicz
Dec 30, 2015·Arthritis Care & Research·Jorge Medina-RosasZahi Touma
Jan 27, 2016·Drugs·César Magro-ChecaGerda M Steup-Beekman
Feb 14, 2016·Lupus·F FarinhaD A Isenberg
Oct 30, 2016·Seminars in Arthritis and Rheumatism·Chrysanthi StaveriStamatis-Nick C Liossis
Feb 2, 2017·Autoimmunity Reviews·S SciasciaM J Cuadrado
Apr 11, 2017·Lupus·M PostalS Appenzeller
Mar 9, 2018·BMC Nephrology·Domenico Paolo Emanuele MargiottaAntonella Afeltra
Apr 11, 2018·Journal of Autoimmunity·Tineke KraaijY K Onno Teng
Jul 22, 2018·F1000Research·Savino SciasciaMaria Laura Bertolaccini
Oct 22, 2018·BMC Nephrology·Francesco FontanaGianni Cappelli
Mar 8, 2019·Autoimmunity Reviews·Andreas KronbichlerDavid R W Jayne
Mar 31, 2019·Annals of the Rheumatic Diseases·Antonis FanouriakisDimitrios T Boumpas