Clinical Efficacy of Routinely Administered Belimumab on Proteinuria and Neuropsychiatric Lupus

Frontiers in Medicine
Marlene PlüßPeter Korsten

Abstract

Background and Objectives: Belimumab (BEL) is a monoclonal antibody approved for the treatment of active systemic lupus erythematosus (SLE) but not for lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE). We aimed to assess BEL's effects on these severe, potentially life-threatening manifestations. Methods: Retrospective observational cohort study using routine clinical data in a case series of patients with SLE receiving BEL. Results: Sixteen patients received BEL therapy for active SLE. Nine were excluded because they had no LN or NPSLE. Six suffered from LN, and one patient had NPSLE. All LN patients received BEL in addition to standard therapy including glucocorticoids, hydroxychloroquine, and mycophenolate mofetil in five cases, and tacrolimus in one case. Three patients with proteinuria >1,000 mg/g creatinine responded well (one complete, two partial renal responses); all other patients had decreasing proteinuria and a reduction in anti-dsDNA levels. The patient with NPSLE who had failed previous therapies had persistent clinical improvement of cutaneous and neuropsychiatric manifestations. There was one mild allergic reaction and one lower respiratory tract infection, but no other adverse event...Continue Reading

References

Apr 11, 2009·Annals of the Rheumatic Diseases·J G HanlyUNKNOWN Systemic Lupus International Collaborating Clinics (SLICC)
Oct 23, 2010·Seminars in Arthritis and Rheumatism·Avraham UntermanGisele Zandman-Goddard
Sep 11, 2014·Rheumatology·Tineke KraaijY K Onno Teng
Oct 30, 2016·Seminars in Arthritis and Rheumatism·Chrysanthi StaveriStamatis-Nick C Liossis
Apr 11, 2018·Journal of Autoimmunity·Tineke KraaijY K Onno Teng
Jul 22, 2018·F1000Research·Savino SciasciaMaria Laura Bertolaccini
Mar 8, 2019·Autoimmunity Reviews·Andreas KronbichlerDavid R W Jayne
Mar 31, 2019·Annals of the Rheumatic Diseases·Antonis FanouriakisDimitrios T Boumpas

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

GraphPad
GraphPad Prism

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.