Clinical efficacy of subgingivally delivered 1.2-mg simvastatin in the treatment of individuals with Class II furcation defects: a randomized controlled clinical trial

Journal of Periodontology
A R PradeepSantosh S Martande

Abstract

Simvastatin (SMV) assists in bone regeneration and has an anti-inflammatory effect when delivered or applied locally. The present clinical trial is designed to investigate the effectiveness of 1.2-mg SMV as a local drug delivery system as an adjunct to scaling and root planing (SRP) for the treatment of Class II furcation defects. Seventy-two patients with mandibular buccal Class II furcation defects were randomized and categorized into two treatment groups: SRP plus placebo (group 1) and SRP plus 1.2-mg SMV (group 2). Clinical parameters were recorded at baseline before SRP and at 3 and 6 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and relative vertical (RVAL) and horizontal (RHAL) attachment levels. At baseline and after 6 months, radiologic assessment of bone defect fill was performed. Both therapies resulted in significant improvements. The decrease in mSBI score at 6 months was greater in group 2 (2.02 ± 0.23) compared with group 1 (1.80 ± 0.22). The mean decrease in PD at 6 months was 1.30 ± 1.0 and 4.05 ± 1.31 mm in groups 1 and 2, respectively. A significantly greater gain in mean RVAL and RHAL was found in group 2 than in group 1 (P <0.05). Furthermore, significantly greater mean pe...Continue Reading

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Citations

Aug 21, 2013·Journal of Conservative Dentistry : JCD·Balaram NaikV Rahul Marshal
Sep 10, 2013·Indian Journal of Pharmacology·Snophia SureshV Pramod
Dec 7, 2013·Journal of Periodontology·Peter MeiselThomas Kocher
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Apr 8, 2020·Journal of Translational Medicine·Shabnam TahamtanAmirhossein Sahebkar
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May 30, 2017·Clinical Oral Investigations·Richard J MironJoseph Choukroun
Jun 20, 2021·Journal of Oral Biosciences·Rafaela Durrer Parolina de CarvalhoKarina Cogo-Müller

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