Clinical efficacy of sublingual immunotherapy in pediatric patients with allergic rhinitis sensitized to house dust mites: comparison to adult patients

Acta Oto-laryngologica
Doo Hee HanChae-Seo Rhee

Abstract

Sublingual immunotherapy (SLIT) with house dust mite (HDM) extracts in school-age children and adolescents seems to be as effective as in adults. SLIT could be recommended as a therapeutic modality in pediatric allergic rhinitis (AR) patients sensitized to HDMs. To investigate the efficacy of HDM SLIT in pediatric patients with AR. Seventy-six patients treated with HDM SLIT for at least 1 year between November 2007 and February 2010 were enrolled in this study. A young age group (n = 54) between 6 and 18 years old was compared with an adult group (n = 22). Standardized extract of HDM (Pangramin® SLIT) was used. Total symptom scores (TSS) and anti-allergic medication scores (AMS) were evaluated before and 1 year after SLIT. TSS improved in both groups, and the change was comparable in the 2 groups (ΔTSS, 5.1 vs 5.3; p = 0.538). Also among the young age group, ΔTSS did not significantly differ between school-age children and adolescents (5.2 vs 4.9, p = 0.429). Thirty-five out of 54 youngsters (64.8%) and 11 out of 22 adults (50.0%) showed improvement in TSS over 30%. AMS were significantly decreased in both groups. ΔAMS tended to be higher in the young age group, but the difference did not reach statistical significance (57.2 vs...Continue Reading

References

Feb 1, 1997·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·T HirschW Leupold
Mar 24, 2000·International Archives of Allergy and Immunology·C AndréH Sicard
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Helen SmithAnthony Frew
Mar 15, 2005·Current Opinion in Allergy and Clinical Immunology·Carlos E Baena-CagnaniWalter G Canonica
May 6, 2006·The Journal of Allergy and Clinical Immunology·Linda S CoxHarold S Nelson
Dec 3, 2008·The Journal of Allergy and Clinical Immunology·Ulrich WahnUNKNOWN SLIT Study Group
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Albrecht BufeFriedrich Kaiser
Apr 10, 2009·The Journal of Allergy and Clinical Immunology·Gabriele Di LorenzoAnne Marie Ditto
Sep 29, 2009·Clinical and Experimental Otorhinolaryngology·Hyun ChangChae-Seo Rhee
Sep 25, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Syuji YonekuraYoichi Kohno

❮ Previous
Next ❯

Citations

Oct 16, 2015·International Forum of Allergy & Rhinology·Frederick M SchafferAndrew R Naples
May 28, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannCarlos E Baena-Cagnani
Apr 30, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A CalderonH Nolte
Feb 11, 2016·World Journal of Clinical Pediatrics·Dimitri PoddigheGian Luigi Marseglia
Apr 25, 2019·Yonsei Medical Journal·Yoo Seob ShinUNKNOWN Allergen and Immunotherapy Work Group of the Korean Academy of Asthma, Allergy and Clinical Immunology (KAAACI)
Apr 25, 2020·International Forum of Allergy & Rhinology·Liang ChenTianlin Li
Jun 17, 2020·American Journal of Rhinology & Allergy·Jin Youp KimDoo Hee Han

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.