Abstract
The ability to identify risk markers for new-onset atrial fibrillation (AF) is critical to the development of preventive strategies, but it remains unknown whether a combination of clinical, electrocardiographic, and echocardiographic parameters predicts the onset of AF. In the present study, we evaluated the predictive value of a combined score that includes these parameters. Methods and Results: We retrospectively studied 1,040 patients without AF who underwent both echocardiography and 24-h Holter electrocardiography between May 2005 and December 2010. During a median follow-up period of 68.4 months (IQR, 49.9-93.3 months), we investigated the incidence of new-onset AF. Of the 1,040 patients, 103 (9.9%) developed AF. Patients who developed AF were older than patients who did not. Total heart beats, premature atrial contraction (PAC) count, maximum RR interval, and frequency of sinus pause quantified on 24-h electrocardiography were associated with new-onset AF. LA diameter (LAD) on echocardiography was also associated with the development of AF. On multivariate Cox analysis, age ≥58 years, PAC count ≥80 beats/day, maximum RR interval ≥1.64 s, and LAD ≥4.5 cm were independently associated with the development of AF. The incid...Continue Reading
References
Sep 1, 1990·Circulation·A J SanfilippoA E Weyman
Aug 1, 1987·The American Journal of Cardiology·P PetersenG Boysen
Oct 1, 1988·American Heart Journal·J T MillerM H Crawford
May 1, 1995·The American Journal of Medicine·A D KrahnT E Cuddy
Feb 1, 1994·Circulation·S M VaziriD Levy
Dec 1, 1996·Circulation·A ElvanD P Zipes
Oct 23, 1997·Circulation·B M PsatyP M Rautaharju
Sep 3, 1998·The New England Journal of Medicine·M HaïssaguerreJ Clémenty
Sep 16, 1998·Circulation·E J BenjaminD Levy
Nov 13, 2002·Journal of the American College of Cardiology·Liza ThomasDavid L Ross
Nov 13, 2002·Journal of the American College of Cardiology·Teresa S M TsangJames B Seward
Dec 31, 2003·The American Journal of Cardiology·Teresa S M TsangJames B Seward
Nov 25, 2004·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Mar 3, 2009·Lancet·Renate B SchnabelEmelia J Benjamin
Apr 21, 2010·Circulation·Zeynep BiniciAhmad Sajadieh
Dec 21, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Boon-Hor ChongChung-Wah Siu
Jul 10, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hung-Yu ChangShih-Ann Chen
Dec 4, 2013·Annals of Internal Medicine·Thomas A DewlandGregory M Marcus
May 16, 2014·Archives of Medical Research·Jun ZhaoGuangping Li
May 16, 2015·PloS One·Petter K NyströmBruna Gigante
Jan 17, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamauchiUNKNOWN CHART-2 Investigators
Citations
Jun 26, 2020·Statistics in Medicine·Antonio Palazón-BruMaría Ángeles Carbonell-Torregrosa
Jul 24, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Eitaro Kodani
May 7, 2020·Open Heart·Muhammad Jawad-Ul-QamarPaulus Kirchhof
Mar 26, 2021·Medicine·Jiang LiuXiaoling Su
Jun 24, 2021·Clinical Cardiology·Kohei SawasakiToyoaki Murohara