Clinical electrophysiology, efficacy and safety of chronic oral cibenzoline therapy in refractory ventricular tachycardia

The American Journal of Cardiology
S T Rothbart, S Saksena

Abstract

The electrocardiographic (ECG) and electrophysiologic (EP) effects, clinical efficacy and safety of oral cibenzoline therapy were evaluated using a twice-daily dosing regimen in patients with refractory ventricular tachycardia (VT). Twenty patients underwent EP studies in the control (drug-free) state and after cibenzoline therapy using an incremental dose-titration protocol. Oral cibenzoline (2.4 to 5.8 mg/kg/day) was administered in doses of 130, 160 or 190 mg at 12-hour intervals. ECG and EP variables, 24-hour ambulatory ECG monitoring and programmed electrical stimulation studies were obtained in the control state and after 11 +/- 4 days of cibenzoline therapy. Cibenzoline therapy prolonged the mean PR interval (from 179 +/- 29 to 201 +/- 36 ms, p less than 0.001), the mean QRS duration (from 107 +/- 21 to 130 +/- 25 ms, p less than 0.001), and the mean QTc interval (from 422 +/- 25 to 460 +/- 42 ms, p less than 0.001). It increased the mean HV interval (from 50 +/- 17 to 65 +/- 20 ms, p less than 0.01) and mean right ventricular effective refractory period (from 245 +/- 24 to 266 +/- 27 ms, p less than 0.01). After cibenzoline therapy, 5 patients (25%) had suppression of inducible sustained VT during programmed electrical ...Continue Reading

References

Jun 1, 1983·International Journal of Cardiology·S SaksenaG Cappello
Aug 1, 1984·Journal of the American College of Cardiology·J B KostisN Cosgrove
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Citations

Nov 1, 1992·Journal of Clinical Pharmacology·E M Vaughan Williams
Feb 1, 1995·Cardiovascular Drugs and Therapy·P BruS Lévy
Dec 5, 1989·The American Journal of Cardiology·P Jaillon, M Drici
Apr 1, 1991·International Journal of Cardiology·V KühlkampL Seipel
Sep 1, 1987·Journal of Clinical Pharmacology·P ZempolJ C Somberg
Aug 29, 2017·Therapeutic Advances in Drug Safety·Jonathan J H Bray, Jules C Hancox

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