PMID: 9549655Apr 29, 1998Paper

Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)- ketoprofen, (R)- flurbiprofen, racemic ketoprofen, and paracetamol: a randomized, single-blind, placebo-controlled trial

Journal of Clinical Pharmacology
T P JerussiD A Handley

Abstract

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid class, causes gastroduodenal hemorrhages and erosions in 10-15% of patients. The (S)- enantiomer exhibits most of the anti-inflammatory properties, with concomitant gastrointestinal toxicity. The (R)- enantiomer, however, was recently found to have analgesic properties independent of prostaglandin inhibition. Seventy-two healthy male volunteers not receiving NSAIDs, alcohol, or anti-ulcer drugs, were enrolled in a randomized, investigator-blind, placebo-controlled trial to evaluate the gastroduodenal tolerance of (R)- ketoprofen 100 mg b.i.d., (R)- flurbiprofen 100 mg b.i.d., racemic ketoprofen 100 mg b.i.d., and paracetamol 1,000 mg b.i.d. Gastroduodenal endoscopies at baseline and after 2.5 days of dosing were used to detect newly occurring hemorrhages and erosions. Adverse events were also recorded. The incidence of submucosal hemorrhages was 4/16 in the (R)- ketoprofen group, 5/16 in the (R)- flurbiprofen group, 12/16 in the racemic ketoprofen group, 1/16 in the paracetamol group, and 1/8 in the placebo group. The incidence of erosions was 2/16 in the (R)- ketoprofen group, 4/16 in the (R)- flurbiprofen group, 10/16 in the racemic ketoprof...Continue Reading

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Citations

Nov 13, 2002·Arthritis and Rheumatism·Steven B Abramson
Apr 29, 1998·Journal of Clinical Pharmacology·D A HandleyJ R McCullough
Aug 4, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Philippe BertinIsabelle Jolivet-Landreau
Sep 11, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·B GalunskaA Di Massa
Feb 8, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leonard Bielory, Andrey Leonov
Nov 8, 2002·Journal of Neurochemistry·T MoriharaG M Cole
Oct 9, 2004·Annals of the Rheumatic Diseases·W ZhangUNKNOWN EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)
Jun 30, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·J A López-VillodresJ A González-Correa
Apr 10, 2002·American Journal of Therapeutics·Lisa B SignorelloWilliam J Blot
Jan 4, 2017·International Journal of Molecular Sciences·Ivonne WobstSabine Grösch

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