PMID: 7028654Sep 1, 1981Paper

Clinical, epidemiologic and microbiologic features of a persistent outbreak of amikacin-resistant Serratia marcescens

Infection Control : IC
J C ArroyoC S Bryan

Abstract

This article describes a prolonged outbreak (January 1977 to February 1980) of amikacin-resistant Serratia marcescens (ARSM) urinary infections and the methods used for its control. Significant factors predisposing to ARSM urinary tract infection included an extended hospital stay, being in the urology ward, and undergoing urologic surgery. There had been on prior administration of amikacin or of other aminoglycosides in 20 of 27 patients with ARSM urinary tract infections. Chronically infected patients who required multiple hospitalizations represented a major reservoir for the perpetuation of the outbreak, overshadowing the importance of aminoglycoside use. Traditional control measures and even a major change in the inanimate environment were only partially effective in controlling the outbreak, but treatment of bacteriuric patients in the urology unit with "second and third generation" cephalosporins interrupted patient-to-patient transmission. No new cases of ARSM bacteriuria appeared in the urology unit in the ensuing 12 months.

References

Mar 1, 1979·The American Journal of Medicine·V L YuT C Merigan
Sep 1, 1977·The Journal of Infectious Diseases·R D Meyer
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·J A WashingtonC Thornsberry
Jun 1, 1977·The American Journal of Medicine·R C MoelleringJ W Poitras
Feb 1, 1981·The American Journal of Medicine·M W Casewell, I Phillips
Sep 1, 1974·Antimicrobial Agents and Chemotherapy·R K HolmesJ P Sanford

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Citations

Oct 7, 2011·Clinical Microbiology Reviews·Steven D Mahlen
Jan 1, 1986·Microbiology and Immunology·R Katoh-KannoS Kimura
Dec 21, 2006·Journal of Korean Medical Science·Baek-Nam KimNam-Hee Ryoo
Jan 1, 1988·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·A E SimorH Bialkowska-Hobrzanska
Aug 14, 2008·The Journal of Antimicrobial Chemotherapy·P M Hawkey
Oct 1, 1984·Journal of Clinical Microbiology·T OkudaH Zen-Yoji
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·J F JohnP A Kresel

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