Clinical epidemiology of chronic viral hepatitis B: A Tuscany real-word large-scale cohort study

World Journal of Hepatology
Cristina StasiFrancesco Cipriani

Abstract

To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus (HBV)-infected patients in the Tuscan public health care system. This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. Of 4015 chronic viral hepatitis patients, 1096 (27.3%) were HBV infected. The case report form was correctly completed for only 833 patients (64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years (only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures (23%), mother-to-child (17%) and sexual transmission (12%). The most represented HBV genotypes were D (72%) and A (14%). Of the patients, 24.7% of patients were HBeAg positive...Continue Reading

References

Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent C TaylorTimothy J Wilt
Nov 10, 2010·Antiviral Therapy·Yun-Fan LiawStephanos Hadziyannis
Jun 26, 2013·Antiviral Therapy·Mónica V Alvarado-MoraJoão R Rebello Pinho
Jul 1, 2014·World Journal of Gastroenterology : WJG·Evangelista SagnelliNicola Coppola
Jul 9, 2014·Clinics and Research in Hepatology and Gastroenterology·Cristina StasiFrancesco Cipriani
Sep 19, 2014·World Journal of Gastroenterology : WJG·Zhao ZhangXiao-Min Xiao
Feb 24, 2015·Infection·Ornella ZuccaroUNKNOWN Study Group
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado
Jan 29, 2016·World Journal of Gastroenterology : WJG·Cristina Stasi, Stefano Milani
Jun 14, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Evangelista SagnelliUNKNOWN EPACRON study Group
Jan 28, 2017·World Journal of Gastroenterology : WJG·Cristina Stasi, Stefano Milani
Mar 16, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Filippo OliveriMaurizia R Brunetto

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Stata
FibroScan

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