Clinical evaluation and management of drug hypersensitivity

Immunology and Allergy Clinics of North America
Gerald W Volcheck

Abstract

Adverse drug reactions are a major health problem in the inpatient and outpatient clinical setting. Although all of the immune mechanisms of drug reactions are not well characterized, a detailed medication history, knowledge of the signs and symptoms associated with known immune mechanisms, and knowledge of the types of medications typically associated with distinct immune reactions are helpful in implicating the causative drug. Standardized testing for drug reactions is limited, especially for non-IgE-mediated reactions. Management consists of stopping the offending drug, treating the acute reaction, and making a determination concerning future use of the drug.

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Citations

Dec 1, 2010·Journal of General Internal Medicine·Yen Chen LiuMalathi Srinivasan
Jun 8, 2006·Journal of Occupational Medicine and Toxicology·Semaan G KosseifiGuha Krishnaswamy
Apr 5, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Syed Mohammad Husain RizviPetter Gjersvik
Jan 9, 2010·The American Journal of the Medical Sciences·Hamiyet Yilmaz YaçsarCoçskun Deniz
Jan 20, 2016·Journal of Medical Case Reports·Caroline Weisser, Moshe Ben-Shoshan
Apr 30, 2016·Mayo Clinic Proceedings·Tanner J BommersbachSimon Kung
Mar 17, 2010·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Marie NameyCynthia Bishop

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