Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.

European Journal of Nuclear Medicine and Molecular Imaging
Mark E SchmidtHartmuth Kolb

Abstract

The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer's disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and selectivity for tau aggregates from human AD brain. We report the dosimetry of [18F] JNJ-64326067 and results of a proof-of-concept study comparing subjects with probable Alzheimer's disease to age-matched healthy controls. [18F] JNJ-64326067 PET scans were acquired for 90 min and then from 120 to 180 min in 5 participants with [18F]-florbetapir PET amyloid positive probable AD (73 ± 9 years) and 5 [18F]-florbetapir PET amyloid negative healthy controls (71 ± 7 years). Whole-body [18F] JNJ-64326067 PET CT scans were acquired in six healthy subjects for 5.5 h in 3 scanning sessions. Brain PET scans were visually reviewed. Regional quantification included kinetic analysis of distribution volume ration (DVR) estimated by Logan graphical analysis over the entire scan and static analysis of SUVr in late frames. Both methods used ventral cerebellar cortex as a reference region. One of the healthy controls had focal areas of PET signal in occipital and parietal cortex underlying the site of a gunshot ...Continue Reading

References

Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J LoganD L Alexoff
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Feb 1, 2008·NeuroImage·Ioannis S GousiasAlexander Hammers
May 27, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dean F WongMichael J Pontecorvo
Sep 17, 2010·Radiology·Christian LangkammerStefan Ropele
Dec 14, 2012·Journal of Alzheimer's Disease : JAD·David T ChienHartmuth C Kolb
Jul 23, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraRobert B Innis
Feb 12, 2015·Journal of Medicinal Chemistry·Manuela ArizaJosé Ignacio Andrés
Oct 28, 2015·Annals of Neurology·Keith A JohnsonReisa Sperling
May 7, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sergey ShcherbininMark A Mintun
May 28, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Eric D HostetlerJeffrey L Evelhoch
Jul 30, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Gil Leurquin-SterkMark E Schmidt
Jan 21, 2017·Journal of Medicinal Chemistry·Frederik J R RomboutsDieder Moechars
Apr 1, 2017·Alzheimer's Research & Therapy·Kok Pin NgPedro Rosa-Neto
Aug 20, 2017·EJNMMI Research·Martin SchainAndrea Varrone
Mar 15, 2018·Brain : a Journal of Neurology·Hugo BothaDavid T Jones
May 20, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tobey J BetthauserBradley T Christian
May 29, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ron Brookmeyer, Nada Abdalla
Aug 12, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hiroto KuwabaraDean F Wong
Mar 17, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Suzanne L BakerWilliam J Jagust
Apr 11, 2019·The New England Journal of Medicine·Robert A SternEric M Reiman

❮ Previous
Next ❯

Citations

Dec 24, 2020·Seminars in Nuclear Medicine·Leonie Beyer, Matthias Brendel
May 25, 2021·Frontiers in Aging Neuroscience·Weiqi BaoYiyun Henry Huang
Aug 3, 2021·Computational Intelligence and Neuroscience·Morteza AminiMahshad Ouchani
Jul 15, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Suzanne L BakerWilliam J Jagust
Mar 21, 2021·Brain : a Journal of Neurology·Steven Y YapKerstin Sander
Feb 8, 2022·European Journal of Nuclear Medicine and Molecular Imaging·Patrick VagenknechtRuiqing Ni

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03239561
NCT03581916

Software Mentioned

Organ Level Internal Dose Assessment ( OLINDA )
OSEM

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.