PMID: 6400416Jan 1, 1983Paper

Clinical evaluation of a flat-plate membrane plasma exchange system

Journal of Clinical Apheresis
L GrossmanG W Buffaloe

Abstract

A new flat-plate membrane plasma separation system specifically designed for therapeutic plasma exchange (TPE) was clinically evaluated in both research and routine clinical settings. The study included a comparison to a currently available centrifugal cell separation system employed for TPE. A total of 267 membrane procedures were performed on 39 patients over a 14-month period. Both qualitative and quantitative studies showed that membrane plasma exchange procedures were equivalent to centrifugal procedures in the removal of plasma constituents from patients. A notable difference between the two types of procedure was the effect on the peripheral blood platelet count: the plasma filtrate from the membrane system was essentially cell-free and platelet counts fell only 11% during the procedure, compared to a 53% decrease during the centrifugation runs. Patient responses to both types of procedure were similar and the frequency of side-effects was low. A sampling of patient opinion revealed a preference for the membrane system for a variety of reasons. Procedure times were shorter with the membrane system because of higher achievable blood flow rates, and thus higher plasma exchange rates, while the overall nursing time requirem...Continue Reading

References

Aug 14, 1976·Lancet·N A BuskardM R Wills
Nov 24, 1977·The New England Journal of Medicine·J V Jones
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Mar 1, 1973·Transfusion·J McCulloughH S Jacob
Sep 18, 1971·British Medical Journal·R PowlesG Hamilton Fairley
Mar 2, 1968·Nature·G JudsonW Greenough
Mar 1, 1968·Transfusion·A L Jones
Jan 1, 1983·Journal of Clinical Apheresis·G W BuffaloeP C Dau
Mar 20, 1980·The New England Journal of Medicine·A I JacobJ J Bourgoignie

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Citations

Mar 21, 2000·Transfusion Science·J B Gorlin
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·E Patten
Jan 1, 1994·Journal of Clinical Apheresis·R E GerhardtC J Wolf
Nov 29, 2001·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Apr 22, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Sadiq Ahmed, Andre Kaplan

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