Clinical evaluation of an immunoturbidimetric D-dimer assay in the diagnostic procedure of deep vein thrombosis and pulmonary embolism

Thrombosis Research
M F Knecht, F Heinrich

Abstract

We investigated 128 patients with suspected deep vein thrombosis and 26 patients with suspected pulmonary embolism. Plasma cross-linked fibrin degradation products were measured instantly by a new rapid and fully quantitative immunoturbidimetric assay (Boehringer Mannheim) which recognizes the D-dimer epitope by antibody-coated latex particles. Diagnosis of deep vein thrombosis was established by either ascending venography (n = 105) or colour duplex ultrasound (n = 8), whereas for the exclusion of deep vein thrombosis only venography was accepted. The sensitivity/specificity for the diagnosis of deep vein thrombosis was 98%/44%. Patients with suspected pulmonary embolism were examined by pulmonary angiography (n = 19) or perfusion lung scanning alone (n = 6), if sufficient. One pulmonary embolism was diagnosed at post-mortem examination. For pulmonary embolism, sensitivity/specificity was 100%/50%. These findings indicate that the new immunoturbidimetric technique is as reliable as former ELISA methods and allows to rule out thromboembolic disorders. D-dimers showed a correlation to the extent of the deep vein thrombosis, proximal thrombosis producing higher D-dimer levels. Patients presenting immediately after the onset of sy...Continue Reading

References

Jul 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·G ReberJ Amiral
May 13, 1996·Archives of Internal Medicine·D M BeckerJ E Humphries

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Citations

Feb 5, 2003·Thrombosis Research·Wouter de MonyéUNKNOWN ANTELOPE Study Group
Jul 2, 2003·Emergency Medicine Journal : EMJ·A WakaiD Winter
Sep 5, 2001·Journal of Clinical Pathology·B H Mavromatis, C M Kessler
Aug 6, 2011·The Tohoku Journal of Experimental Medicine·Mitsuru ShiotaHiroshi Hoshiai
Oct 26, 2005·AJR. American Journal of Roentgenology·Mark S ParkerNarinder N Sethi
Jul 22, 2009·AJR. American Journal of Roentgenology·Rajan T GuptaVictor F Tapson
Feb 11, 2012·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Toshiyasu OgataYasushi Okada
Jan 28, 2003·Annals of Emergency Medicine·UNKNOWN American College of Emergency Physicians Clinical Policies Committee, UNKNOWN Clinical Policies Committee Subcommittee on Suspected Pulmonary Embolism
Jun 16, 2005·QJM : Monthly Journal of the Association of Physicians·S GoodacreF Morris
Sep 22, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Cecilia M JennersjöTomas L Lindahl
May 15, 2004·Clinical Chemistry·Steven W HeimJohn T Philbrick
Oct 28, 2003·Clinical Chemistry·Michael D BrownJeffery A Kline
Dec 9, 2004·AACN Clinical Issues·Kenneth J Rempher, Jean Little
Jul 17, 1999·Medizinische Klinik·C Ranke, H J Trappe
May 18, 2011·The Tohoku Journal of Experimental Medicine·Mitsuru ShiotaHiroshi Hoshiai
Sep 13, 2013·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Zhihong XuQing Jiang
Mar 17, 2021·European Heart Journal. Quality of Care & Clinical Outcomes·J M KauppiT Kiviniemi
Jun 27, 2003·Annals of Emergency Medicine·UNKNOWN American College of Emergency Physicians (ACEP) Clinical Policies Committee, UNKNOWN ACEP Clinical Policies Subcommittee on Suspected Lower-Extremity Deep Venous Thrombosis
Jul 26, 2005·Thrombosis Research·Piia von LodeKim Pettersson

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