Clinical evaluation of carcinoembryonic and carbohydrate antigens as cancer biomarkers to monitor palliative chemotherapy in advanced stage gastric cancer

Current Problems in Cancer
Muhammad AbbasChen Dingding

Abstract

Carcinoembryonic antigen (CEA), carbohydrate antigen (CA)-125, CA19-9, and CA72-4 are often found modulated parameters in gastric cancer. Our present study is focused to evaluate the synchronization of these biomarkers in response to palliative chemotherapy. A retrospective study was conducted on 216 gastric cancer patients undergoing first-line cisplatin chemotherapy along with antiangiogenic regimen. Blood samples were taken and analyzed biochemically and statistically. Progression occurred in 78 of 216 patients and the median progression-free survival (PFS) was 5 months. For serum CEA, the median PFS was 4 versus 7 months for elevated and normal groups respectively (P = 0.01). The median PFS for normal and elevated CA19-9 and CA72-4 was 6 vs 4 months respectively (P = 0.001). In the multivariate Cox regression model, elevated pretreatment level of CEA, CA19-9, and distant metastases were independent factors associated with increased risk of progression (P = 0.021, P = 0.000, P = 0.006, respectively). Conclusively, elevated pretreatment level of CEA and CA19-9 is correlated with high risk of progression and worse prognosis. Moreover, an additional antiangiogenic therapy is more effective in decreasing cancer biomarker level a...Continue Reading

Citations

Nov 14, 2019·Journal of Clinical Laboratory Analysis·Xiuchong YuJunming Guo
Jul 15, 2020·Drug Delivery and Translational Research·Mirza Muhammad Faran Ashraf BaigMuhammad Tayyab Ansari
Jul 22, 2019·Journal of Food and Drug Analysis·Mirza Muhammad Faran Ashraf BaigMuhammad Tayyab Ansari
Apr 18, 2019·Biotechnology Letters·Ke-Tao JinXiao-Zhou Mou
Nov 4, 2020·Archives of Environmental & Occupational Health·Eno E EssienMuhammad Abbas
Jul 5, 2021·European Journal of Pharmacology·Yan-Ping LiMing Xu
Sep 15, 2021·Technology in Cancer Research & Treatment·Cheng-You JiaDa Fu

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