Clinical evaluation of haploidentical hematopoietic combined with human umbilical cord-derived mesenchymal stem cells in severe aplastic anemia

European Journal of Medical Research
Lixin XuXiaoxiong Wu

Abstract

This study not only evaluated the clinical effects of treatment using haploidentical hematopoietic stem cells (haplo-HSCs) combined with human umbilical cord mesenchymal stem cells (UC-MSCs) in patients with severe aplastic anemia (SAA), but also investigated the factors related to graft versus host disease (GVHD). Cotransplantation of haplo-HSCs and UC-MSCs was performed in 24 SAA patients. The conditioning regimens consisted of rabbit anti-human T-lymphocyte immunoglobulin (ATG), cyclophosphamide, and fludarabine with or without busulfan. GVHD was prevented using cyclosporine A, ATG, anti-CD25 monoclonal antibody, and mycophenolate material. The incidence of acute GVHD was 50%. The incidence of severe acute GVHD was not related to gender, age, donor-recipient relations, and patient/donor pair, while patient/donor pair (r = 0.541, P = 0.022) was significantly correlated with incidence of chronic GVHD. Upon follow-up for a median of 13 months, 5 of the 24 patients (20.8%) were dead. The survival rates at 3 and 6 months in all patients were 87.5% (21/24) and 83.3% (20/24), respectively. Cotransplantation of haplo-HSCs combined with UC-MSCs was an effective and safe approach for the treatment of patients with SAA. The appropriate...Continue Reading

References

Dec 8, 2004·Stem Cells·Hwai-Shi WangChin-Chang Chen
Apr 21, 2012·Blood·Phillip Scheinberg, Neal S Young
Dec 24, 2013·Blood·Massimo F MartelliAndrea Velardi

❮ Previous
Next ❯

Citations

Mar 23, 2018·Stem Cell Research & Therapy·Lu ZhaoLanjuan Li
Aug 6, 2020·International Journal of Molecular Sciences·Bruno FattizzoWilma Barcellini
Jan 7, 2021·Cancers·Bruno FattizzoChiara Caprioli
Jun 19, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Arzu AkçayGülyüz Öztürk

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.