Abstract
This study not only evaluated the clinical effects of treatment using haploidentical hematopoietic stem cells (haplo-HSCs) combined with human umbilical cord mesenchymal stem cells (UC-MSCs) in patients with severe aplastic anemia (SAA), but also investigated the factors related to graft versus host disease (GVHD). Cotransplantation of haplo-HSCs and UC-MSCs was performed in 24 SAA patients. The conditioning regimens consisted of rabbit anti-human T-lymphocyte immunoglobulin (ATG), cyclophosphamide, and fludarabine with or without busulfan. GVHD was prevented using cyclosporine A, ATG, anti-CD25 monoclonal antibody, and mycophenolate material. The incidence of acute GVHD was 50%. The incidence of severe acute GVHD was not related to gender, age, donor-recipient relations, and patient/donor pair, while patient/donor pair (r = 0.541, P = 0.022) was significantly correlated with incidence of chronic GVHD. Upon follow-up for a median of 13 months, 5 of the 24 patients (20.8%) were dead. The survival rates at 3 and 6 months in all patients were 87.5% (21/24) and 83.3% (20/24), respectively. Cotransplantation of haplo-HSCs combined with UC-MSCs was an effective and safe approach for the treatment of patients with SAA. The appropriate...Continue Reading
References
Oct 1, 1974·Transplantation·H GlucksbergE D Thomas
Aug 5, 2000·Bone Marrow Transplantation·G HaleH Waldmann
Feb 15, 2001·The New England Journal of Medicine·W I BensingerF R Appelbaum
Aug 15, 2002·Blood·Stephen CoubanUNKNOWN Canadian Bone Marrow Transplant Group
Dec 8, 2004·Stem Cells·Hwai-Shi WangChin-Chang Chen
Oct 22, 2005·Leukemia·M OkamotoC Shimazaki
Jul 29, 2006·Stem Cells·Rosa YañezJuan A Bueren
Apr 24, 2007·Bone Marrow Transplantation·B GeorgeM Chandy
Aug 7, 2009·International Journal of Laboratory Hematology·X ZhangW Xu
Sep 8, 2009·Haematologica·Sébastien MauryUNKNOWN Severe Aplastic Anemia Working Party, European Group for Blood and Marrow Transplantation (EBMT-SAAWP)
Apr 16, 2011·Transplantation·Kang-Hsi WuJing-Long Huang
Apr 21, 2012·Blood·Phillip Scheinberg, Neal S Young
May 9, 2012·Pediatrics·Hengxiang WangZikuan Guo
Dec 12, 2012·Bone Marrow Transplantation·S Maury, M Aljurf
Jan 16, 2013·Annals of Hematology·Seung-Hwan ShinJong Wook Lee
Jul 12, 2013·Annals of Hematology·Yamei WuZhongchao Han
Nov 5, 2013·Stem Cell Research·Yamei WuZhongchao Han
Dec 24, 2013·Blood·Massimo F MartelliAndrea Velardi
Jan 5, 2014·Pediatric Hematology and Oncology·Yingjian SiZhichun Feng
Oct 7, 2014·Bone Marrow Transplantation·N GuptaM Dhamija
Mar 24, 2015·Bone Marrow Transplantation·S R JaiswalS Chakrabarti
Jun 7, 2016·British Journal of Haematology·Hua ZhuJing Chen
Citations
Mar 23, 2018·Stem Cell Research & Therapy·Lu ZhaoLanjuan Li
Aug 6, 2020·International Journal of Molecular Sciences·Bruno FattizzoWilma Barcellini
Jan 7, 2021·Cancers·Bruno FattizzoChiara Caprioli
Jan 10, 2021·Scientific Reports·Yingling ZuYongping Song
Feb 6, 2021·Stem Cell Research & Therapy·Ruonan LiJun Shi
May 17, 2021·British Journal of Haematology·Richard W ChildsGeorg Aue
May 21, 2021·Frontiers in Cell and Developmental Biology·Yufeng ShangFuling Zhou
Jun 19, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Arzu AkçayGülyüz Öztürk
Jun 26, 2021·Frontiers of Medicine·Hongchen LiuJinsong Yan