Clinical evaluation of hepatitis B core-related antigen in chronic hepatitis B and hepatocellular carcinoma patients

Clinica Chimica Acta; International Journal of Clinical Chemistry
Shipeng ChenChun-Fang Gao

Abstract

Hepatitis B core-related antigen (HBcrAg) has been revealed as an important marker of Hepatitis B virus (HBV) infection recently. We aimed to evaluate the HBcrAg assay for indication of HBV loads in chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) patients and assess the association between HBcrAg/cccDNA and HCC recurrence. HBcrAg was measured by chemiluminescence enzyme immunoassay. Intrahepatic covalently closed circular DNA (cccDNA) was measured by real-time PCR with TaqMan fluorescent probes based on liver specimens from 89 HCC patients. HBcrAg correlated positively with HBV DNA irrespective of HBeAg status. Both HBcrAg and HBV DNA were associated with cccDNA in patients with elevated serum HBV DNA (>4 log IU/mL). In patients with non-elevated HBV DNA (≤4 log IU/mL), no relationship between HBV DNA and cccDNA was observed, but we still documented a modest correlation between HBcrAg and cccDNA. Finally, the recurrence-free survival rates were significantly lower in HCC patients with high intrahepatic cccDNA and serum HBcrAg levels than those with low cccDNA/HBcrAg levels (p = 0.035, p = 0.003 respectively). HBcrAg not only can serve as a biomarker to assess HBV loads in patients as well as provide a good method f...Continue Reading

Citations

May 12, 2019·Genes·Takako Inoue, Yasuhito Tanaka
Jun 17, 2020·Clinical and Molecular Hepatology·Takako Inoue, Yasuhito Tanaka
Feb 7, 2020·International Journal of Molecular Sciences·Ian BaudiYasuhito Tanaka
Sep 19, 2020·Microorganisms·Magda Rybicka, Krzysztof Piotr Bielawski
May 7, 2021·Seminars in Liver Disease·Hye Won LeeHenry Lik-Yuen Chan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.