Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries

Veterinary Anaesthesia and Analgesia
Nasser Vesal, Payman Zare

Abstract

To evaluate the effects of intranasal benzodiazepines (midazolam and diazepam), alpha(2)-agonists (xylazine and detomidine) and their antagonists (flumazenil and yohimbine) in canaries. Prospective randomized study. Twenty-six healthy adult domesticated canaries of both sexes, weighing 18.3 +/- 1.0 g. In Study 1 an attempt was made to determine the dose of each drug that allowed treated canaries to be laid in dorsal recumbency for at least 5 minutes, i.e. its effective dose. This involved the evaluation of various doses, during which equal volumes of the tested drug were administered slowly into each nostril. In study 2 the onset of action, duration and quality of sedation induced by each drug at its effective dose were evaluated. The efficacy of flumazenil and yohimbine in antagonizing the effects of the sedative drugs was also studied. In study 1 administration of 25 microL per nostril diazepam (5 mg mL(-1) solution) or midazolam (5 mg mL(-1) solution) to each bird caused adequate sedation within 1-2 minutes; birds did not move when placed in dorsal recumbency. After administration of 12 microL per nostril of either xylazine (20 mg mL(-1)) or detomidine (10 mg mL(-1)), birds seemed heavily sedated and assumed sternal recumben...Continue Reading

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Citations

Jun 29, 2013·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Amin Bigham Sadegh
Feb 13, 2016·Veterinary Anaesthesia and Analgesia·Débora Ph SchäfferArianne P Oriá
Jan 16, 2013·Journal of Veterinary Pharmacology and Therapeutics·A S Bigham, A K Zamani Moghaddam
Jan 21, 2017·Journal of Avian Medicine and Surgery·Marie KubiakKevin Eatwell
Mar 24, 2020·Veterinary Anaesthesia and Analgesia·Omar Ahmad ZaheerHugues Beaufrère

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