Clinical evaluation of paresthesia steering with a new system for spinal cord stimulation

Neurosurgery
Jan HolsheimerP de Sutter

Abstract

The goal was to evaluate, in a clinical study, the predicted performance of the transverse tripolar system for spinal cord stimulation, particularly the steering of paresthesia, paresthesia coverage, and the therapeutic range of stimulation. Six transverse tripolar electrodes were implanted in the lower thoracic region in four patients experiencing chronic neuropathic pain. Electrode positions, relative to the spinal cord, were estimated from computed tomographic scans. A dual-channel stimulator was used for initial percutaneous tests, and an implanted single-channel stimulator was used for follow-up test sessions. Nine "balance" settings and several cathode-anode combinations were used with the dual-channel and single-channel stimulator, respectively. In each test, the increase of paresthesia coverage from the perception threshold to the discomfort threshold was registered on a body map and the corresponding voltages were recorded. Paresthesia steering occurred in all but one patient. The normalized steering score, enabling quantitative comparisons of paresthesia steering among tests and patients, showed that maximum paresthesia steering occurred when the electrode was at least 3 mm dorsal to the spinal cord and centered <2 mm...Continue Reading

References

Jan 1, 1991·Stereotactic and Functional Neurosurgery·G BarolatB Ketcik
Sep 1, 1967·The Journal of Physiology·G Werner, B L Whitsel
Nov 19, 1965·Science·R Melzack, P D Wall
Jan 1, 1980·Medical & Biological Engineering & Computing·D T JoblingL S Illis
Jan 1, 1980·International Rehabilitation Medicine·M R DimitrijevicA M Sherwood
Feb 1, 1994·The Journal of Physiology·J P Hunter, P Ashby
Sep 1, 1995·Medical & Biological Engineering & Computing·J HolsheimerN R Tas
Jan 1, 1995·Acta Neurochirurgica. Supplement·J HolsheimerJ He
Jul 1, 1996·Medical & Biological Engineering & Computing·J J Struijk, J Holsheimer

❮ Previous
Next ❯

Citations

Sep 22, 2000·Current Review of Pain·V C Anderson, Z Israel
Jan 21, 2011·Journal of Neural Engineering·V SankarasubramanianP Veltink
Apr 1, 2000·Neuromodulation : Journal of the International Neuromodulation Society·J Holsheimer
Jan 1, 2006·Neuromodulation : Journal of the International Neuromodulation Society·Richard B NorthLoredana Petrucci
Jul 1, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Timothy Denison, Brian Litt
Jul 1, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Gabriela Molnar, Giancarlo Barolat
Apr 1, 2007·Neuromodulation : Journal of the International Neuromodulation Society·Ljubomir ManolaDavid Peterson
Jul 1, 2006·Neuromodulation : Journal of the International Neuromodulation Society·John C OakleyJan Holsheimer
Jan 22, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Leonardo KapuralDaniel I Sessler
Dec 18, 2013·Current Pain and Headache Reports·Krishna Kumar, Syed Rizvi
Jul 1, 1998·Neuromodulation : Journal of the International Neuromodulation Society·J Holsheimef, G Barolat
Apr 1, 2003·Neuromodulation : Journal of the International Neuromodulation Society·M Aló Kenneth
Nov 15, 2014·Neuromodulation : Journal of the International Neuromodulation Society·Timothy DeerRobert Levy
Dec 12, 2018·Applied Bionics and Biomechanics·Gerald E Loeb
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven FalowskiAshwini Sharan
Mar 16, 2007·Expert Review of Medical Devices·Antonio FolettiEric Buchser
Aug 23, 2011·Neuromodulation : Journal of the International Neuromodulation Society·Vishwanath SankarasubramanianPeter Veltink
Jul 1, 1999·Neuromodulation : Journal of the International Neuromodulation Society·D S BennettC A Feler
Jul 1, 2004·Neuromodulation : Journal of the International Neuromodulation Society·John OakleyKerry Bradley
Apr 4, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Jan Holsheimer, Jan R Buitenweg
Jan 12, 2020·Pain Practice : the Official Journal of World Institute of Pain·Byeong Ho OhYoung Seok Park
Mar 21, 2002·Neurosurgery·Kenneth M Aló, Jan Holsheimer
Jan 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Jan Holsheimer
Jul 1, 1999·Neuromodulation : Journal of the International Neuromodulation Society·K M Aló
Jan 1, 2001·Neuromodulation : Journal of the International Neuromodulation Society
Aug 31, 2018·Neurologia Medico-chirurgica·Takafumi TaneiToshihiko Wakabayashi
Nov 19, 2002·Spine·John C Oakley, Joshua P Prager
Jan 1, 1999·Neuromodulation : Journal of the International Neuromodulation Society·W A WesselinkH B Boom
Mar 19, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Takamitsu YamamotoAtsuo Yoshino
Oct 15, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Vishwanath SankarasubramanianPeter Veltink
Mar 23, 2021·Scientific Reports·Antonietta CannaSilvia Mangia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.