The diagnosis of IgE-mediated immediate reactions to penicillins can be supported by in vivo or in vitro tests using classical benzylpenicillin determinants. The wide variety of beta-lactams and the description of new specificities requires a re-evaluation of the different tests available. The objective was to evaluate the diagnostic capacity of Pharmacia CAP System RAST FEIA amoxicilloyl c6 (AXO) and benzylpenicilloyl c1 (BPO) in patients with a documented IgE-mediated penicillin allergy. We studied 129 patients in five groups. Groups 1, 2, and 3 had developed an immediate reaction after penicillin treatment. Group 1 (n=19) were skin test positive to amoxicillin (AX) and/or BPO and/or minor determinant mixture (MDM); group 2 (n=29) were skin test positive to AX but negative to BPO and MDM; and group 3 (n=26) were skin test negative to all determinants, the diagnosis being confirmed by a previous repetitive history or controlled administration. Two control groups, one with nonimmediate reactions -- group 4 (n=25) -- and one with good tolerance to penicillin -- group 5 (n=30) -- were included. All samples were analyzed in vitro for AXO and BPO, and the results compared to the in vivo diagnosis. AX was the drug most often involve...Continue Reading
Allergy to penicillin with good tolerance to other penicillins; study of the incidence in subjects allergic to beta-lactams
Drug-induced cutaneous reactions. A report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982
Detection of penicillin allergy of the immediate type by radioimmunoassay of reagins (IgE) to penicilloyl conjugates
Radioallergosorbent test with conjugates specific for 'minor' haptenic determinants in the diagnosis of IgE-mediated penicillin allergy in man
Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross-reactivity with cephalosporin
Clinical cross-reactivity between amoxicillin and cephadroxil in patients allergic to amoxicillin and with good tolerance of penicillin
Toward an in vitro test for the diagnosis of allergy to penicillins. Synthesis, characterization, and use of beta-lactam and beta-lactam metabolite poly-L-lysines which recognize human IgE antibodies
Immunologic response to different determinants of benzylpenicillin, amoxicillin, and ampicillin. Comparison between urticaria and anaphylactic shock
Differences in the immunological responses in drug- and virus-induced cutaneous reactions in children
IgE to penicillins with different specificities can be identified by a multiepitope macromolecule: Bihaptenic penicillin structures and IgE specificities
Penicillin allergy evaluation: experience from a drug allergy clinic in an Arabian Gulf Country, Kuwait
The specificity of tests for anti-beta-lactam IgE antibodies declines progressively with increase of total serum IgE.
Late-onset bolus intravenous beta-lactam antibiotic adverse reaction: short-lived symptoms during drug administration and associated laboratory abnormalities
Use of commercial anti-penicillin IgE fluorometric enzyme immunoassays to diagnose penicillin allergy
The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams
The diagnostic interpretation of basophil activation test in immediate allergic reactions to betalactams
Influence of total serum IgE levels on the in vitro detection of beta-lactams-specific IgE antibodies
Continued need of appropriate betalactam-derived skin test reagents for the management of allergy to betalactams
Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy
Skin testing and drug provocation in the diagnosis of nonimmediate reactions to aminopenicillins in children
Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project
Diagnosis of drug hypersensitivity in children and adolescents: discrepancy between physician-based assessment and results of testing
Identification and frequency of circulating CD4(+) T lymphocytes specific to Benzylpenicillin in healthy donors
Role of minor determinants of amoxicillin in the diagnosis of immediate allergic reactions to amoxicillin
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