Abstract
The therapeutic effects of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents, vancomycin (VCM), teicoplanin (TEIC), and arbekacin (ABK), depend on their concentrations in blood. Therefore, therapeutic drug monitoring (TDM) is important when these antibiotics are used. In the hematological ward at Tokushima University Hospital, pharmacists have ordered the measurement of blood VCM, TEIC, and ABK concentrations to promote the use of TDM in accordance with an agreed protocol since 2013. Moreover, the infection control team includes several medical disciplines and has advised on the optimal treatment using VCM, TEIC, and ABK since 2013. This study aimed to investigate the clinical effectiveness of these pharmacist interventions. We retrospectively studied 145 cases in which patients were treated with VCM, TEIC, or ABK between January 2012 and December 2013 in the hematological ward at Tokushima University Hospital. The patients were divided into a control group (71 cases) and an intervention group (74 cases), and their clinical outcomes were compared. The rate of achievement of effective drug concentrations significantly increased in the intervention group (74%), compared to the rate in the control group (55%). Moreove...Continue Reading
References
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Aug 1, 1989·British Journal of Clinical Pharmacology·E J BeggN W Taylor
Dec 1, 1994·The Annals of Pharmacotherapy·T E Welty, A K Copa
Jul 14, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tohru Masaoka
Jun 28, 2006·Critical Care Medicine·Eric A J Hoste, John A Kellum
Dec 2, 2006·Research in Social & Administrative Pharmacy : RSAP·Brian J IsettsMargaret B Artz
Jan 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of Americaa
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
Apr 7, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaharu ImauraYasuhiko Yamada
Sep 7, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kazuaki MatsumotoKatsushi Yamada
Nov 9, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takashi UedaMotoi Uchino
May 16, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kazuaki MatsumotoToshimi Kimura
Feb 4, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kenji OkadaYoshio Takesue
Oct 28, 2014·Bone Marrow Transplantation·H AriizumiT Nakamaki
Jan 29, 2016·Journal of Pharmaceutical Health Care and Sciences·Makoto KajizonoToshiaki Sendo
Citations
Sep 18, 2018·Pharmacoepidemiology and Drug Safety·Shunsuke IshidaKeisuke Ishizawa
Sep 13, 2019·European Journal of Clinical Pharmacology·Naoto OkadaKeisuke Ishizawa
Aug 25, 2020·Journal of Pharmaceutical Health Care and Sciences·Shungo ImaiYoh Takekuma
May 19, 2020·European Journal of Hospital Pharmacy. Science and Practice·Jiaxing ZhangWenyi Zheng
May 11, 2018·Antimicrobial Resistance and Infection Control·M H F SakeenaAndrew J McLachlan
Jun 15, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·M H F SakeenaAndrew J McLachlan
Mar 19, 2019·Frontiers in Pharmacology·Jiaxing ZhangJuan Xie
Oct 6, 2020·Frontiers in Pharmacology·Jiaxing ZhangJuan Xie
Jun 19, 2021·The Journal of Hospital Infection·T MonmaturapojM C Watson
Oct 30, 2021·Basic & Clinical Pharmacology & Toxicology·Toshinori HiraiTakuya Iwamoto