Clinical Evaluation of Pharmacist Interventions in Patients Treated with Anti-methicillin-Resistant Staphylococcus aureus Agents in a Hematological Ward

Biological & Pharmaceutical Bulletin
Naoto OkadaKeisuke Ishizawa

Abstract

The therapeutic effects of anti-methicillin-resistant Staphylococcus aureus (MRSA) agents, vancomycin (VCM), teicoplanin (TEIC), and arbekacin (ABK), depend on their concentrations in blood. Therefore, therapeutic drug monitoring (TDM) is important when these antibiotics are used. In the hematological ward at Tokushima University Hospital, pharmacists have ordered the measurement of blood VCM, TEIC, and ABK concentrations to promote the use of TDM in accordance with an agreed protocol since 2013. Moreover, the infection control team includes several medical disciplines and has advised on the optimal treatment using VCM, TEIC, and ABK since 2013. This study aimed to investigate the clinical effectiveness of these pharmacist interventions. We retrospectively studied 145 cases in which patients were treated with VCM, TEIC, or ABK between January 2012 and December 2013 in the hematological ward at Tokushima University Hospital. The patients were divided into a control group (71 cases) and an intervention group (74 cases), and their clinical outcomes were compared. The rate of achievement of effective drug concentrations significantly increased in the intervention group (74%), compared to the rate in the control group (55%). Moreove...Continue Reading

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Citations

May 19, 2020·European Journal of Hospital Pharmacy. Science and Practice·Jiaxing ZhangWenyi Zheng
May 11, 2018·Antimicrobial Resistance and Infection Control·M H F SakeenaAndrew J McLachlan
Jun 15, 2019·Pharmacy : Journal of Pharmacy, Education and Practice·M H F SakeenaAndrew J McLachlan
Oct 30, 2021·Basic & Clinical Pharmacology & Toxicology·Toshinori HiraiTakuya Iwamoto

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