Clinical evaluation of probucol in hypercholesteremia: individual lipoprotein responses and inhibitory effect on carotid atherosclerosis progression

Journal of Cardiovascular Pharmacology
D BaldassarreC R Sirtori

Abstract

Probucol treatment has been evaluated in 140 patients with hypercholesterolemia attending a single Lipid Clinic, in an attempt to identify the relations between lipid/lipoprotein responses and patient characteristics. Probucol was administered as a single drug at the standard dose (0.5 g tablets b.i.d.) for at least 6 months. One-hundred (71%) patients displayed a reduction of low-density lipoprotein cholesterol (LDL-C), which was significantly correlated with the baseline LDL-C level (r = 0.64; p < 0.0001). Most of the patients (90%) also responded with a reduction of high-density lipoprotein cholesterol (HDL-C); the HDL-C reduction was also directly related to baseline HDL cholesterolemia (r = 0.67, p < 0.0001). A highly significant correlation was found between the individual LDL-C and HDL-C responses. Eleven patients who continued with probucol treatment had a B-mode ultrasonographic investigation performed at baseline and after 24 months. No changes in carotid mean and maximal intimal-medial thickness were recorded, in contrast to an increase (i.e., indicative of atherosclerosis progression) in matched patients with hypercholesterolemia receiving other lipid-lowering regimens. Our report underlines that probucol can still ...Continue Reading

References

Nov 1, 1992·Metabolism: Clinical and Experimental·M NaruszewiczJ Davignon
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R McPhersonY L Marcel
Feb 1, 1991·Circulation·D H BlankenhornE C Wickham
Mar 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S E MargitićJ L Probstfield
Oct 1, 1989·Atherosclerosis·S MaedaA Noma
Nov 9, 1989·The New England Journal of Medicine·D J Gordon, B M Rifkind
Jul 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FranceschiniC R Sirtori
Jun 27, 1986·The American Journal of Cardiology·J Davignon
Jun 27, 1986·The American Journal of Cardiology·A YamamotoB Kishino
Apr 1, 1984·Annals of Internal Medicine·C A DujovneM Garty
Mar 1, 1984·Annals of Internal Medicine·Z J Twardowski, K D Nolph
Feb 23, 1995·The New England Journal of Medicine·T J AndersonP Ganz
Jan 1, 1994·Pharmacology & Therapeutics·G FranceschiniL Calabresi
Aug 1, 1994·Stroke; a Journal of Cerebral Circulation·D BaldassarreC R Sirtori
Mar 1, 1994·Circulation·M GalliR Giubbini
Jan 1, 1993·European Journal of Clinical Pharmacology·K SakuK Arakawa
Jan 1, 1993·European Journal of Clinical Pharmacology·Y OhyaM Fujishima
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar

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Citations

Dec 21, 2000·Current Atherosclerosis Reports·K D Pfuetze, C A Dujovne
Dec 21, 2000·Current Atherosclerosis Reports·A L Catapano, E Tragni
Apr 13, 2011·Hepatology International·Yu-Tao ZhanXiao-Xia Guo
Aug 12, 1999·European Journal of Pharmacology·H BultK E Matthys
Dec 30, 1998·Current Opinion in Lipidology·A FaggiottoA L Catapano
May 20, 2008·Cardiovascular Therapeutics·Cesare R Sirtori, Giuliana Mombelli
Jun 21, 2016·Diabetes Research and Clinical Practice·John D BagdadeP V Subbaiah
Dec 29, 2000·Current Opinion in Cardiology·A L CatapanoE Tragni
Dec 17, 2008·Annals of Medicine·Anders G Olsson
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S NagaoJ J Grantham

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