Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Ka Lip ChewSunil K Sethi

Abstract

This study aimed to evaluate the diagnostic performance of the Abbott Architect SARS-CoV-2 IgG assay in COVID-19 patients. Residual sera from 177 symptomatic SARS-CoV-2-positive patients and 163 non-COVID-19 patients were tested for antibody with the Abbott SARS-CoV-2 IgG assay (Abbott Diagnostics, Chicago, USA). Clinical records for COVID-19 patients were reviewed to determine the time from onset of clinical illness to testing. Specificity of the assay was 100.0% (95%CI: 97.1-100.0%). The clinical sensitivity of the assay varied depending on time from onset of symptoms, increasing with longer periods from the onset of clinical illness. The clinical sensitivity at ≤6 days was 8.6% (7/81; 95%CI: 3.8-17.5%), at 7-13 days 43.6% (17/39; 95%CI: 28.2-60.2%), at 14-20 days 84.0% (21/25; 95%CI: 63.1-94.7%), and at ≥21 days 84.4% (27/32; 95%CI: 66.5-94.1%). Clinical sensitivity was higher in the ≥14-day group compared to <14 days. There were no differences between the 14-20-day and ≥21-days groups; the combined clinical sensitivity for these groups (≥14 days) was 84.2% (49/57; 71.6-92.1%). The Abbott SARS-CoV-2 IgG test has high specificity. Clinical sensitivity was limited in the early stages of disease but improved from 14 days after ...Continue Reading

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Citations

Aug 28, 2020·Journal of Clinical Microbiology·Michael J Loeffelholz
Sep 8, 2020·Clinical Chemistry·Mei San TangChristopher W Farnsworth
Sep 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly E HansonReem A Mustafa
Oct 22, 2020·Clinical Chemistry·Raymond T SuhandynataRobert L Fitzgerald
Sep 10, 2020·Archives of Pathology & Laboratory Medicine·Shaun S TanSunil K Sethi
Nov 1, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hadi M YassineGheyath K Nasrallah
Dec 19, 2020·Journal of Virological Methods·Felipe Pérez-GarcíaJuan Cuadros-González
Aug 3, 2020·The Journal of Infection·Fergus HamiltonDavid Arnold
Sep 15, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Julien MarletCatherine Gaudy-Graffin
Sep 13, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Charlotte CharpentierNadhira Fidouh-Houhou
Jan 19, 2021·Proceedings·Jonathan KopelAbhilash Perisetti
Feb 13, 2021·International Medical Case Reports Journal·Maher Abbas, Carl-Johan Törnhage
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Methods Mentioned

BETA
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS )
Excel

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