PMID: 9535601Apr 16, 1998Paper

Clinical evaluation of serum prostate-specific antigen-alpha1-antichymotrypsin complex values in diagnosis of prostate cancer: a cooperative study

International Journal of Urology : Official Journal of the Japanese Urological Association
M KuriyamaJ Shimazaki

Abstract

We studied the clinical significance of serum prostate-specific antigen bound to alpha1-antichymotrypsin (PSA-ACT) values determined with a newly developed enzyme immunoassay. Serum PSA-ACT values were determined in a total of 652 sera. Clinical utility for the diagnosis of prostate cancer was compared to that of Tandem-R PSA and gamma-seminoprotein (gamma-Sm). The new enzyme immunoassay is based on the use of the Stanford reference as an international standard for PSA assays. Serum PSA-ACT values ranged from less than 0.10 to 1.4 ng/mL in healthy males (n = 100) while values in patients with benign prostatic hyperplasia (n = 155) averaged 3.4 +/- 3.8 ng/mL (mean +/- SD). In patients with prostate cancer, serum PSA-ACT values increased significantly with progression of the clinical stage and there were statistically significant differences between benign prostatic hyperplasia and each stage of prostate cancer except for stage A. Using BPH levels as controls (4.8 ng/mL for PSA-ACT, 7.2 ng/mL for PSA, 3.8 ng/mL for gamma-Sm, and 2.4 ng/mL for the complexed/free PSA ratio of PSA-ACT/gamma-Sm), specificity was 80%. The sensitivity of prostate cancer detection was 79% for PSA-ACT, 77% for PSA, 57% for gamma-Sm, and 46% for the ratio...Continue Reading

References

Jun 1, 1994·International Journal of Urology : Official Journal of the Japanese Urological Association·M Kuriyama
Jan 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·A F Prestigiacomo, T A Stamey

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Citations

Jun 5, 2013·Indian Journal of Surgical Oncology·Mohan Adhyam, Anish Kumar Gupta
Oct 23, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Wolfgang HerrmannJürgen Geisel
Jul 27, 1999·Japanese Journal of Clinical Oncology·M KuriyamaY Ban
Jul 12, 2002·The Urologic Clinics of North America·Michael K Brawer
Mar 29, 2002·Cancer·Takashi SaikaUNKNOWN Okayama Urological Cancer Collaborating Group
May 1, 2008·Expert Review of Endocrinology & Metabolism·Wolfgang Herrmann, Markus Herrmann
Dec 19, 2003·The Urologic Clinics of North America·Matthew B Gretzer, Alan W Partin

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