PMID: 9441116Dec 1, 1996Paper

Clinical evaluation of serum type IV collagen 7S in idiopathic pulmonary fibrosis

Respirology : Official Journal of the Asian Pacific Society of Respirology
I KasugaK Toyama

Abstract

Type IV collagen is one of the major components of the basement membrane (BM). 7S domain (7S collagen) of type IV collagen is an N-terminal peptide which is stable against protease and heat. We investigated serum concentration of 7S collagen in patients with idiopathic pulmonary fibrosis (IPF) and other pulmonary diseases. The aim of this study was to evaluate whether changes in the serum concentration of 7S collagen reflect the fibrotic process of IPF. We measured the concentration of serum 7S collagen with radioimmunoassay in patients with IPF, chronic pulmonary emphysema (CPE), sarcoidosis, infectious pulmonary diseases (IPD) and normal healthy controls. We also monitored 7S collagen during the clinical course in some patients with IPF and investigated the correlation between the serum 7S collagen, and lactate dehydrogenase (LDH) and erthrocyte sedimentation rate (ESR) in patients with IPF. Patients with IPF showed significantly higher serum concentration of 7S collagen than other pulmonary diseases and healthy controls. The serum concentration of 7S collagen significantly decreased in IPF patients who showed roentgenographic improvement after corticosteroid treatment. There was a correlation between the serum 7S collagen an...Continue Reading

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Citations

Aug 26, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Antje Prasse, Joachim Müller-Quernheim
Jul 7, 2015·Expert Review of Respiratory Medicine·Ilaria CampoFrancesco Bonella
Jan 27, 2009·The Mount Sinai Journal of Medicine, New York·Adam S Morgenthau, Maria L Padilla
Oct 31, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Hirokazu TakahashiKazuma Fujimoto
May 26, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Hirokazu UrushiyamaAkira Shimizu
Jan 21, 2017·International Archives of Occupational and Environmental Health·Min YuGuang Jia
Feb 24, 2018·Journal of Gastroenterology and Hepatology·Yuji EsoHiroshi Seno
Nov 24, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Pedro LlontopNorberto Santana-Rodríguez
Dec 23, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshihide ShimaTakeshi Okanoue

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