PMID: 7541234Jul 1, 1995Paper

Clinical evaluation of seven tumour markers in lung cancer diagnosis: can any combination improve the results?

British Journal of Cancer
M PlebaniA Cipriani

Abstract

In this study we compared the diagnostic utility of: (1) neuron-specific enolase (NSE); (2) squamous cell carcinoma antigen (SCC); (3) carcinoembryonic antigen (CEA); and (4) cytokeratin markers (CYFRA 21-1, TPA, TPM, TPS) in patients with small-cell lung cancer (SCLC) (21 cases) and non-small-cell lung cancer (94 cases). For comparison we also studied 66 patients with benign lung diseases and nine with pleural mesothelioma. NSE levels in SCLC patients were significantly higher than those in all the other groups studied. No significant variations were found among the SCC levels in all groups. CEA levels in patients with adenocarcinoma were significantly higher than those in all other groups studied. CYFRA 21-1 serum levels significantly increased in patients with squamous cell carcinoma and mesothelioma, while TPA, TPS and TPM increased in patients with lung cancer irrespective of the histological type. In patients with SCLC, high levels of all markers except SCC were found when the disease was extensive. In patients with non-SCLC, the highest levels of all tumour markers were usually found in those with advanced disease, although CYFRA 21-1 gave a sensitivity of 44% when a specificity of 95% was fixed in stage I non-SCLC patie...Continue Reading

Citations

Aug 1, 1996·Journal of Surgical Oncology·M PlebaniA Corsini
Oct 30, 2013·BioMed Research International·Rong WangYunde Liu
Jan 6, 2000·The Tohoku Journal of Experimental Medicine·S KobayashiS Fujimura
Mar 21, 2002·Expert Review of Molecular Diagnostics·G Buccheri, D Ferrigno
Jun 9, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Hui-jie YangYi-xi Bao
May 19, 2006·Journal of Hepato-biliary-pancreatic Surgery·Takahiro UenishiShoji Kubo
Mar 17, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Juan WangWei Huang
Feb 24, 2017·Surgery Today·Haruhiko Nakamura, Toshihide Nishimura
Jul 6, 2004·Clinical Biochemistry·Rafael MolinaJosep M Augé
Sep 8, 2009·Experimental and Molecular Pathology·Javier de CastroJesús Sánchez-Yagüe

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