Abstract
The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS858), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 urban-based prospective cohorts: the Malmö Diet and Cancer (n=29 295) and the Malmö Preventive Project (n=9367) and a weighted BP-GRS858 based on 858 SNPs was calculated. At baseline, we found a difference of 9.0 mm Hg (systolic BP) and 4.8 mm Hg (diastolic BP) between the top and the bottom quartile of BP-GRS858. In Malmö Preventive Project, the top versus bottom quartile of BP-GRS858 was associated with a doubled risk of incident hypertension (odds ratio, 2.05 [95% CI, 1.75-2.39], P=1.4×10-21), a risk higher than that of body mass index, as evaluated in quartiles. In Malmö Diet and Cancer, significant association was found between the age and sex-adjusted BP-GRS858 and the incidence of total cardiovascular events, stroke, coronary artery disease, heart failure, atrial fibrillation, and total mortality. Most of these associations remai...Continue Reading
References
Sep 1, 1989·Journal of Personality and Social Psychology·J A Krosnick, D F Alwin
Jan 1, 1993·Journal of Internal Medicine
Jan 1, 1993·Journal of Internal Medicine·G BerglundS A Larsson
Aug 1, 1996·American Journal of Hypertension·A M GrandiA Venco
May 2, 2006·American Journal of Hypertension·Iris B GoldsteinDonald Guthrie
Oct 4, 2007·Human Molecular Genetics·Alan Y Deng
May 12, 2009·Nature Genetics·Daniel LevyCornelia M van Duijn
Nov 26, 2009·European Journal of Epidemiology·J Gustav SmithOlle Melander
Apr 9, 2010·Journal of Hypertension·Paolo VerdecchiaGianpaolo Reboldi
Dec 13, 2012·Hypertension·Cristiano FavaOlle Melander
Jun 1, 2014·Journal of Hypertension·Cristiano FavaOlle Melander
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
Jul 4, 2015·Bioinformatics·Mitchell J Machiela, Stephen J Chanock
Sep 24, 2015·European Heart Journal·Hayato TadaDov Shiffman
Oct 29, 2015·Journal of the American Heart Association·Shakia T HardyChristy L Avery
Feb 27, 2016·Circulation·Iftikhar J KulloKent R Bailey
Dec 14, 2016·The New England Journal of Medicine·Amit V KheraSekar Kathiresan
Sep 1, 2017·Frontiers in Cardiovascular Medicine·Joshua W KnowlesThemistocles L Assimes
Sep 28, 2017·Nature Genetics·Helen R WarrenUNKNOWN UK Biobank CardioMetabolic Consortium BP working group
Nov 15, 2017·Genome Medicine·Cathryn M Lewis, Evangelos Vassos
May 24, 2018·Nature Reviews. Genetics·Ali TorkamaniEric J Topol
Aug 15, 2018·Nature Genetics·Amit V KheraSekar Kathiresan
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Sep 19, 2018·Nature Genetics·Evangelos EvangelouUNKNOWN Million Veteran Program
Dec 24, 2018·Nature Genetics·Ayush GiriTodd L Edwards
Mar 1, 2019·Philosophy, Ethics, and Humanities in Medicine : PEHM·A C PalkD J Stein
Apr 2, 2019·Frontiers in Cardiovascular Medicine·Yuqi ZhaoXia Yang
May 3, 2019·Pulse·Yan Wang, Ji-Guang Wang
Aug 1, 2019·Human Molecular Genetics·Samuel A LambertMichael Inouye
Oct 5, 2019·Journal of Hypertension·Alan Y Deng, Annie Ménard