Clinical evaluation of the serodiagnostic value of enzyme-linked immunosorbent assay for Rhodococcus equi infection in foals

Equine Veterinary Journal
T HiguchiS Takai

Abstract

An enzyme-linked immunosorbent assay (ELISA) for detection of serum IgG antibodies against Tween 20-extracted antigen of strain ATCC 6939 was applied in Hidaka, Japan to a total of 752 sick foals showing a variety of signs of infectious disease. An optical density (OD) value of more than 0.3 was tentatively fixed to be positive on the basis of readings made of healthy horse sera in previous studies. During a 2 year study, 138 of the 752 sick foals showed an OD value of 0.3 or higher and were designated as 'suspected of R. equi infection'. Age distribution during the initial medical examination of the 138 seropositive foals was significant in that most (64%) foals were age 31-60 days, with a sharp decrease in subjects beyond that age. Of the 138 foals suspected of having R. equi infection, 34 foals (25%) showed OD values of over 0.9 at the initial medical examination, in addition to high blood leucocyte counts and serum fibrinogen and alpha-globulin values. The infectious foals had been treated with antibiotics just before and after serodiagnosis and 126 foals (91%) recovered from the disease. However, no clinical improvement was observed in 12 foals (9%). At necropsy, these foals revealed suppurative pneumonia and lymphadenitis...Continue Reading

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Citations

Mar 15, 2001·Comparative Immunology, Microbiology and Infectious Diseases·S TakaiT Anzai
Feb 27, 2003·Comparative Immunology, Microbiology and Infectious Diseases·V CuteriC Valente
Jan 18, 2011·Journal of Comparative Pathology·K SonmezS Takai
Aug 3, 2006·The Veterinary Clinics of North America. Equine Practice·Yvonne A Elce
Oct 13, 2005·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·T PhumoonnaM W Heuzenroeder
Oct 13, 2006·Comparative Immunology, Microbiology and Infectious Diseases·A R AttiliV Cuteri
Sep 19, 2002·The Journal of Veterinary Medical Science·Teruhiko YuyamaShinji Takai
Nov 19, 2003·American Journal of Veterinary Research·Misty C JordanRonald J Martens
Apr 14, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tomoyuki ShibaharaKoichi Kadota
Jul 13, 2017·Journal of the South African Veterinary Association·Sharon Tirosh-LevyAmir Steinman
Dec 5, 2002·The Veterinary Record·N Y OzgurS Takai
Sep 6, 2005·American Journal of Psychoanalysis·Joseph Francese
Sep 27, 2002·Journal of the American Veterinary Medical Association·Ronald J MartensRonnie E Edwards
Jun 7, 2007·The Journal of Veterinary Medical Science·Masahisa WataraiHiroshi Suzuki

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