PMID: 40893Jan 1, 1978

Clinical evaluation of two biphasic and one triphasic norgestrel/ethinyl estradiol regimens

International Journal of Fertility
A LarrañagaF Navas Filho


Four hundred and fifty-eight women were followed for 3,586 cycles in a controlled, randomized, open trial designed to compare two biphasic and one triphasic norgestrel/ethinyl estradiol (ee) regimens. The three regimens are effective and no pregnancies were reported. Cycle control was good with all three regimens but the incidence of intermenstrual bleeding was higher with the triphasic. With this regimen, total hormonal ingestion is well below the lowest fixed dose norgestrel/ethinyl estradiol preparation (300 mcg norgestrel and 30 mcg ee) in the original 10:1 ratio. It is concluded that the staggering of hormonal doses opens the possibility of contraception with less hormone intake than is possible when a fixed dose regimen is used.

Related Concepts

Drug Evaluation
Oral Contraceptives, Phasic
Progynon C
Combined Oral Contraceptives

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.