Abstract
To evaluate the diagnostic application of urinary transforming growth factor-beta1 (TGF-beta1) and serum alpha-fetoprotein (AFP) levels in hepatocellular carcinoma (HCC), TGF-beta1 and AFP were determined in 94 patients with cirrhotic HCC and in 94 sex- and age-matched patients with cirrhosis alone. TGF-beta1 and AFP levels in HCC were higher than in cirrhosis alone (P = 0.0001). There is an inverse correlation between TGF-beta1 and log AFP (r = -0.292, P = 0.004). Multivariate analysis indicated that TGF-beta1 and AFP were closely associated, in a dose-related fashion, with the development of HCC. Receiver-operating characteristic (ROC) curves were used to determine the optimal cut-off values of TGF-beta1 (50 microg g(-1) creatinine) and AFP (100 ng ml(-1)). Both TGF-beta1 and AFP showed a high specificity (99%) and positive likelihood ratio. The sensitivity was 53.1% for TGF-beta1 and 55.3% for AFP. The determination of both markers in parallel significantly increased the diagnostic accuracy (90.1%) and sensitivity (84%), with a high specificity (98%) and positive likelihood ratio (40.0). In conclusion, TGF-beta1 and AFP are independent tumour markers of HCC and may be used as complementary tumour markers to discriminate HCC ...Continue Reading
Citations
Jun 27, 2008·Intervirology·Seung Kew Yoon
Aug 1, 2007·Biomarkers in Medicine·Nikki P Y LeeJohn M Luk
Jan 30, 2002·Cancer·Byung-Cheol SongDong Jin Suh
Jun 27, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Piera BalzariniGiulio Alessandri
Apr 9, 2016·World Journal of Hepatology·Jin Un KimSimon D Taylor-Robinson
Nov 27, 2015·World Journal of Hepatology·Francesca M TrovatoGuglielmo M Trovato
Apr 22, 2005·Scandinavian Journal of Gastroenterology·J F TsaiC Y Dai
May 23, 2012·Digestive Diseases and Sciences·Xing GuChun-Fang Gao
Aug 1, 2007·Biomarkers in Medicine·Jeng-Eing JengJung-Fa Tsai
Jan 26, 2016·The FEBS Journal·Isabel FabregatUNKNOWN IT-LIVER Consortium
Jul 4, 2015·World Journal of Hepatology·Magdy Hamed Attwa, Shahira Aly El-Etreby
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jen-Eing JengJung-Fa Tsai
Mar 9, 2010·Clinical Chemistry·Catharine M SturgeonUNKNOWN National Academy of Clinical Biochemistry
Oct 17, 2008·Cancer Research·Anna BenettiGiulio Alessandri
Dec 12, 2020·Talanta·Sultan AitekenovRostislav Bukasov
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
Oct 12, 2000·Biochemical and Biophysical Research Communications·W N ChenS W Teng