PMID: 3242386Jan 1, 1988Paper

Clinical evaluation with long-term follow-up of flutamide and estramustine as initial treatment of metastatic carcinoma of the prostate

American Journal of Clinical Oncology
J E JohanssonG Zador

Abstract

Thirty patients with metastatic cancers but with no serious cardiovascular (CV) conditions were randomly assigned to receive treatment either with flutamide (250 mg x 3) (F) or with estramustine (280 mg x 2) (E). Clinical examination, bone scan, laboratory measurements were performed before randomization and at regular intervals thereafter. During an observation period of between 1 and 2.5 years, F was discontinued in one case (7%) because of icterus, and E in three cases (20%) because of CV complications. Of the remaining 14 F-treated patients, 13 responded initially. Eleven of them relapsed, and five died of cancer. In the corresponding group of 12 E-treated patients, there were 11 primary responders. Of these, only two relapsed and died, as did the only nonresponder. The difference between the two groups with regard to relapse is significant (p less than 0.01), but not with regard to mortality. In the present material, there was an initial favorable response to F without signs of CV complications and with maintained libido in most cases. However, due to the significantly increased risk for relapse compared with E, F cannot be recommended as single therapy except in cases where estrogens are contraindicated or when interferen...Continue Reading

Citations

Mar 1, 1990·The American Journal of the Medical Sciences·L BalducciW Sexton
Oct 21, 2006·The Cochrane Database of Systematic Reviews·Mike ShelleyMalcolm D Mason
Apr 28, 2006·Bioorganicheskaia khimiia·L E GolubovskaiaV M Rzheznikov
Dec 24, 2002·Prostate Cancer and Prostatic Diseases·A V KaisaryT Morris
Jan 1, 1990·The Journal of International Medical Research·A V BonoP Preti

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