May 30, 2020

Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
C RodrigoS Rajapakse

Abstract

Repurposing hydroxychloroquine (HCQ) and chloroquine (CQ) as antiviral agents is a re-emerging topic with the advent of new viral epidemics. To summarize evidence from human clinical studies for using HCQ or CQ as antiviral agents for any viral infection. PubMed, EMBASE, Scopus, Web of Science for published studies without time or language restrictions; Cochrane Clinical Trial Registry and Chinese Clinical Trials Registry for trials registered after 2015; MedRxiv for preprints within the last 12 months. Study eligibility criteria were interventional and prospective observational studies (with or without a control group). Participants were adults and children with a confirmed viral infection. Interventions included the use of CQ or HCQ as antiviral agent in one or more groups of the study. Two authors independently screened abstracts, and all authors agreed on eligible studies. A meta-analysis was planned if studies were available which were similar in terms of participants, intervention, comparator and outcomes. Nineteen studies (including two preprints) were eligible (HIV 8, HCV 2, dengue 2, chikungunya 1, COVID-19 6). Nine and ten studies assessed CQ and HCQ respectively. Benefits of either drug for viral load suppression in ...Continue Reading

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Mentioned in this Paper

Hepatitis C virus
Antiviral Agents
Virus Diseases
Clinical Trials
Virus
Pharmacologic Substance
Dengue Fever
Chikungunya virus
Meta Analysis (Statistical Procedure)
Viral Load Measurement

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