Clinical experience in acute overdosage of diphenidol

Journal of Toxicology. Clinical Toxicology
C C Yang, J F Deng

Abstract

Diphenidol (Cephadol, Vontrol), an antiemetic agent used in the treatment of vomiting and vertigo, has been reported to cause various adverse effects including drowsiness, hypotension, confusion, hallucination, restlessness, and other antimuscarinic effects. Serious toxic effects might be anticipated after intentional or accidental ingestion. Retrospective analysis of all case records of the PCC-Taiwan defining diphenidol overdose during 1985-1996. The data of 21 patients with diphenidol overdose were analyzed; 17 were < 3 years old and unintentionally poisoned, in contrast to the suicide attempts by four adults. The average amount of ingestion was 222.5 mg with a range of 25-800 mg. Most patients manifested only transient CNS, cardiovascular, or oculo-facial effects, but four children suffered from severe toxicity after an ingestion of 11.7-80 mg/kg diphenidol. Commonly reported toxicity in diphenidol overdose included facial flush (10), tachycardia, restlessness (6), seizures (4), dyspnea, drowsiness, mydriasis, coma, and fever (3). With supportive therapy, a good recovery was the rule except for one fatality of a 2 1/2-year-old boy who ingested 15 mg/kg diphenidol and presented with recurrent seizures, hypotension, respirato...Continue Reading

References

Apr 1, 1975·Chest·A J WassermanJ D Proctor
Nov 1, 1972·Journal of Medicinal Chemistry·C KaiserC L Zirkle
May 1, 1968·Journal of the American Geriatrics Society·N M Rowan
Sep 18, 1972·JAMA : the Journal of the American Medical Association·R C Duvoisin
Feb 1, 1971·The American Journal of Psychiatry·J F Heiser, J C Gillin
Mar 1, 1969·Archives of Otolaryngology·R D KatzV Goodhill
Jul 1, 1968·Canadian Anaesthetists' Society Journal·J P Dechêne, R Desrosiers
Jan 1, 1993·Journal of Toxicology. Clinical Toxicology·D FrankelB M Murray
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·C C YangJ F Deng
Feb 3, 1951·Journal of the American Medical Association·J B WYNGAARDEN, M H SEEVERS

❮ Previous
Next ❯

Citations

Oct 21, 2015·Forensic Science, Medicine, and Pathology·Lin ZhangYiwu Zhou
Apr 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiangqi LiMingjun Gu
May 28, 2020·Frontiers in Physiology·Conor J BloxhamWalter G Thomas
Mar 9, 2019·Annals of Clinical and Translational Neurology·Leo BrueggemanAlexander G Bassuk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

DICP : the Annals of Pharmacotherapy
T Graves
Journal of Toxicology. Clinical Toxicology
Robert D GairDebra A Kent
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
D Kasantikul
© 2022 Meta ULC. All rights reserved