Clinical experience of prophylactic treatment in von Willebrand disease

Thrombosis Research
S Lethagen

Abstract

The prophylactic treatment of bleeding in von Willebrand disease (vWD) has a long history in Sweden, having been first initiated in the late 1950s. The clinical experience of the prophylaxis of vWD in Sweden is described in the current review of a retrospective study of 37 patients from three haemophilia centres receiving prophylaxis for vWD. Prophylaxis with a plasma concentrate (fraction I-0 or Factor VIII) effectively reduced the median number of bleeds per year, prevented joint arthropathy in those who started prophylaxis at a young age, and improved the quality of life of all patients with vWD, particularly those with type 3 disease. This study demonstrates that the long-term prophylactic treatment with von Willebrand Factor (vWF)/FVIII concentrate (Haemate-P, ZLB Behring) in vWD is warranted in the majority of patients with type 3 disease.

References

Mar 1, 1976·Acta paediatrica Scandinavica·I M NilssonA Ahlberg

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Citations

Jul 20, 2007·Annals of Hematology·Massimo FranchiniGiuseppe Lippi
Mar 26, 2009·Blood·Simon F De MeyerKaren Vanhoorelbeke
Jan 18, 2015·Thrombosis Research·Wolfgang MiesbachErhard Seifried
Sep 27, 2012·Blood Reviews·K P M van GalenF W G Leebeek
Dec 2, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·R HowmanG Barrese
Jun 23, 2012·Acta Haematologica·Augusto B Federici, Paula James
Oct 21, 2011·Brazilian Dental Journal·Leonardo Perez FaveraniIdelmo Rangel Garcia Júnior

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