Clinical experience of stereotactic radiosurgery at a linear accelerator for intraocular melanoma

Melanoma Research
Alena FurdovaMichal Gregus

Abstract

Long-term results with linear accelerator LINAC-based stereotactic radiosurgery for intraocular uveal malignant melanoma were assessed. A retrospective study was carried out of patients with uveal melanoma after a 1-day session stereotactic radiosurgery at LINAC in Slovakia. In the period 2001-2015, a group of 150 patients with uveal melanoma (139 choroidal melanoma, 11 ciliary body melanoma) was treated. The median tumor volume at baseline was 0.5 cm (with range from 0.2 to 1.6 cm). Tumors ranged in size from 2.4 to 20.8 mm in basal diameter and from 2.0 to 18.3 mm in thickness. The therapeutic dose was 35.0 Gy by 99% of dose volume histogram. Older age at treatment was correlated with the largest basal tumor diameter, tumor thickness, and TNM stage. The survival after stereotactic irradiation was 96% in 1 year, 93% in 2 years, 84% in 5 years, 80% in 7 years, and 53% in 11 years. In 20 (13.3%) patients, secondary enucleation was necessary because of complications (secondary glaucoma). Enucleation-free interval ranged from 1 to 6 years. The median age at death was lower (65.7 years) for patients who died from metastatic disease than for those who died from any other cause (75.0 years). Survival rates at 5-year intervals and the...Continue Reading

References

Jul 13, 2000·Ophthalmology·A J MuellerA Kampik
Jul 27, 2001·Melanoma Research·A D SinghJ A Shields
May 17, 2003·Ophthalmology·Arun D Singh, Allan Topham
Jun 19, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Karin DieckmannRichard Pötter
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Bertil DamatoR Douglas Errington
Jul 27, 2006·Technology in Cancer Research & Treatment·Mark A HendersonRobert D Timmerman
May 6, 2009·The British Journal of Ophthalmology·H KremaN Laperriere
Jun 25, 2009·European Journal of Ophthalmology·Carlo MosciNicole Iborra
May 3, 2011·European Journal of Ophthalmology·Alena FurdovaPeter Slezak
Jun 9, 2016·Annals of Translational Medicine·Marc OlivaJosep M Piulats

❮ Previous
Next ❯

Citations

Sep 1, 2018·Vestnik oftalmologii·A F Brovkina
Sep 13, 2020·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·P ZahorjanováM Štubňa
Apr 11, 2020·Nature Reviews. Disease Primers·Martine J JagerBertil E Damato
Jul 31, 2020·International Journal of Molecular Sciences·Pooneh Chokhachi BaradaranBozena Smolkova
May 21, 2021·The Journal of Craniofacial Surgery·Alena FurdovaZuzana Pridavkova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.