Clinical experience of tacrolimus with everolimus in heart transplantation

Transplantation Proceedings
S-S WangC-T Shun

Abstract

Tacrolimus (Tac) in combination with mycophenolate mofetil is widely used after heart transplantation (HT). Everolimus (EVR), a new potent proliferation signal inhibitor can be used with a carcineurin inhibitor to reduce the occurrence of rejection. The purpose of this study was to evaluate the efficacy and safety of Tac combined with EVR in de novo HT. From January 2009 to April 2011, 33/62 patients who underwent HT were prescribed Tac and EVR as de novo immunosuppression. The main exclusion criteria were poor kidney function (serum creatinine > 2.8 mg/dL), panel-reactive antibodies > 25%, donors > 60 years old, or cold ischemia time > 6 hours. All patients received Tac (C0 blood level 5-10 ng/mL during the first 6 months, then 3-5 ng/mL), EVR (C0 target 3-8 ng/mL), and corticosteroids. After transplantation, routine examinations included echocardiogram and protocol endomyocardial biopsy. There was no operative mortality. The 1- and 3-year actuarial survivals were 95.74% ± 3.49%. One patient who had undergone coronary artery bypass grafting previously and received intra-aortic balloon pumping and extracorporeal membrane oxygenator-assisted cardiopulmonary resuscitation before HT died of Aspergillus septicemia 58 days after HT....Continue Reading

References

Aug 29, 2003·The New England Journal of Medicine·Howard J EisenUNKNOWN RAD B253 Study Group
Dec 24, 2004·The New England Journal of Medicine·Philip F Halloran
Jul 1, 2005·The New England Journal of Medicine·Jeffrey D Hosenpud
Dec 21, 2007·The New England Journal of Medicine·Henrik EkbergUNKNOWN ELITE-Symphony Study
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorMarshall I Hertz
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul AuroraMarshall I Hertz
May 1, 2010·Transplantation Proceedings·S-S WangC-T Shun

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Citations

Apr 29, 2014·Transplantation Proceedings·S-S WangS-H Chu
May 7, 2013·Transplantation Reviews·Andreas ZuckermannHans B Lehmkuhl
Oct 23, 2014·Pharmacoepidemiology and Drug Safety·Chia-Lin ChouYueh-Ching Chou
May 29, 2016·Transplantation Proceedings·Y-J WangS-S Wang
Apr 21, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Yu-Ning HuChwan-Yau Luo

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