Clinical experience with a bioartificial liver in the treatment of severe liver failure. A phase I clinical trial

Annals of Surgery
F D WatanabeA A Demetriou

Abstract

The purpose of this study was to develop a bioartificial liver (BAL) to treat patients with severe liver failure until they can be either transplanted or recover spontaneously. Severe acute liver failure is associated with high mortality. Liver transplantation has emerged as an effective therapy for patients who did not respond to standard management. However, because of the donor organ shortage and urgent need for transplantation, many patients die before they can be transplanted and others do not survive after transplantation, primarily because of intracranial hypertension. Three groups of patients with severe acute liver failure were treated with the BAL. In group 1 (n = 18) were patients with fulminant hepatic failure (FHF), in group 2 (n = 3) were patients with primary nonfunction (PNF) of a transplanted liver, and in group 3 (n = 10) were patients with acute exacerbation of chronic liver disease. Patients in groups 1 and 2 were candidates for transplantation at the time they entered the study, whereas patients in group 3 were not. In group 1, 16 patients were "bridged" successfully to transplantation, 1 patient was bridged to recovery without a transplant, and 1 patient died because of concomitant severe pancreatitis. In ...Continue Reading

References

Sep 10, 1976·European Journal of Clinical Investigation·C O RecordR Williams
Jan 1, 1977·Lancet·W H Rutherford
Apr 1, 1977·American Journal of Surgery·G N CooperH T Randall
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N L SussmanJ H Kelly
Apr 1, 1995·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·E MorsianiA A Demetriou
Feb 1, 1995·Scandinavian Journal of Gastroenterology·J HotzK Rose
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·A A DemetriouH Rosen
May 1, 1994·Annals of Surgery·J RozgaM McGrath
Nov 1, 1993·The American Journal of Gastroenterology·I J FoxM F Sorrell
Dec 16, 1993·The New England Journal of Medicine·W M Lee
Feb 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J RozgaA A Demetriou
May 1, 1993·Annals of Surgery·J RozgaA A Demetriou
Jan 1, 1996·Journal of Clinical Apheresis·F D Watanabe, A A Demetriou

❮ Previous
Next ❯

Citations

Aug 14, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Y Braunfeld
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S L NybergR H Wiesner
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S Nyberg
May 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S R MitznerR Schmidt
Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S L Nyberg
Sep 1, 2005·Surgery Today·Yujo KawashitaTakashi Kanematsu
Apr 5, 2011·Journal of Materials Science. Materials in Medicine·Andreas K NusslerThomas S Weiss
Oct 10, 2007·Veterinary Research Communications·M FerrariA Lanfranchi
Nov 23, 2010·Frontiers of Medicine·Yi-Tao Ding, Xiao-Lei Shi
Sep 12, 2000·Current Gastroenterology Reports·P Rosenthal
Nov 30, 2005·Current Treatment Options in Gastroenterology·Jelica KurtovicRoger Williams
May 26, 2004·Transplant Immunology·Clare Selden, Humphrey Hodgson
Jun 11, 1999·Disease-a-month : DM·S Kaur, S Cotler
Jul 5, 2003·The Journal of Surgical Research·Masaya ShitoMehmet Toner
Mar 12, 1999·The Surgical Clinics of North America·A O ShakilD J Kramer
Dec 20, 2000·Transplantation Proceedings·Y J HwangJ M Chung
Jan 3, 2001·Transplantation Proceedings·J LerutP F Laterre
Jan 3, 2001·Transplantation Proceedings·M MuracaG Carturan
Jan 3, 2001·Transplantation Proceedings·U CilloD F D'Amico
Mar 27, 2001·Transplantation Proceedings·A DoniniF Bresadola
Jun 20, 2002·Transplantation Proceedings·E F M Wijdicks, S L Nyberg
Feb 20, 2003·Transplantation Proceedings·N KobayashiN Tanaka
Feb 20, 2003·Transplantation Proceedings·D C MearsA G R Sheil
Sep 10, 2003·Transplantation Proceedings·J A FernándezP Parrilla
Sep 2, 1998·Transplantation Proceedings·V CornoF Bresadola
Mar 20, 1999·Transplantation Proceedings·F D WatanabeA A Demetriou
Jan 5, 2000·Transplantation Proceedings·A G SheilJ Watson
Jun 19, 2001·Current Opinion in Biotechnology·E T Bloom
Sep 17, 2002·Journal of the American College of Surgeons·John F PatzerUNKNOWN Bioartificial Liver Program Investigators
Jan 12, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A C PuvianiE Morsiani
May 17, 2003·Metabolic Engineering·Christina ChanMartin L Yarmush

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.