PMID: 8938344Feb 1, 1996Paper

Clinical experience with conservative surgery for vaginal endodermal sinus tumor

Journal of Pediatric Surgery
E H HwangB S Kim

Abstract

Two cases of vaginal endodermal sinus tumor (EST), a rare pediatric malignancy, were managed with conservative surgery followed by adjuvant chemotherapy. The first case involved a 9-month-old girl with EST of the vagina, who was treated with a partial vaginectomy and VAC regimen (vincristine, actinomycin D, cyclophosphamide) during a 2-year period. The serum alpha-fetoprotein (AFP) level returned to normal after excision of the tumor, and it remained normal throughout the treatment period. There was no evidence of disease 30 months after diagnosis. The second case involved an 8-month-old girl with EST of the vagina, who was treated with local excision of the mass through a vaginotomy. The VAC regimen was administered, but the serum AFP level remained elevated. A follow-up abdominopelvic computed tomography scan, taken 4 months after the operation, showed local recurrence of the tumor. The VAC regimen was then changed to a BEP regimen (bleomycin, etoposide, cisplatin). The serum AFP level returned to normal after 2 courses of the new regimen, and no tumor was visible on the follow-up magnetic resonance imaging study. For vaginal EST, primary conservative surgery and adjuvant chemotherapy are attractive measures to preserve both ...Continue Reading

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Citations

Apr 29, 1999·Medical and Pediatric Oncology·L F LopesB de Camargo
Sep 28, 2005·Indian Journal of Pediatrics·Vijay KumarM Basant
Nov 23, 2006·Journal of Pediatric Hematology/oncology·Judith LacyLisa Allen
Jul 20, 2002·The Journal of Urology·Liann N HandelMartin A Koyle
Mar 29, 2000·The Journal of Urology·B H BochnerB E Hardy
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qiong-Lan TangLin Xue
Dec 8, 2009·Journal of Pediatric and Adolescent Gynecology·Nisar A WaniAbdul Qayum
Mar 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zhen YuanHuifang Huang
Oct 4, 2005·Pediatric Blood & Cancer·Monica TerenzianiLuigi Piva
May 2, 2015·Journal of Pediatric Hematology/oncology·Revathi RajagopalHai Peng Lin
Jul 7, 2020·Journal of Pediatric and Adolescent Gynecology·Allison C MayhewKrista J Childress
Dec 30, 1999·Current Problems in Cancer·F J Rescorla, P P Breitfeld
Jun 23, 2021·Journal of Pediatric and Adolescent Gynecology·Giovanni TorinoGiovanni Di Iorio

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