Clinical experience with cotransplantation of peripheral nerve and adrenal medulla in patients with Parkinson's disease

Transplant International : Official Journal of the European Society for Organ Transplantation
J J López-LozanoR Moreno

Abstract

Coimplants of adrenal medulla (AM) and peripheral nerve (PN) in animal models of Parkinson's disease (PD) have shown that AM cells survive longer, tend to show neuronal phenotype, and enhance sprouting of host fibers. Since 1987, our implants of perfused AM and fetal ventral mesencephalon (FVM) in PD patients have achieved varying degrees of clinical improvement. If the donor tissue determines the improvement, different types of implants should result in qualitatively and quantitatively different degrees of improvement. The purpose of this study is to determine whether or not the clinical course, improvement slope, and reduction of medication observed in PD patients who undergo tissue transplantation (Tx) depend on the donor tissue type. In a pilot study, four grade IV-V PD patients received implants of precoincubated autologous AM and intercostal nerve in the caudate nucleus (open surgery). Clinical assessment was based on international scales (UPD) as reported for Tx of FVM and perfused AM. There were no systemic or neurologic complications. Four years post-Tx, longer On phases and improved PD symptoms (ADL and motor-UPD) in On and Off persist in four cases, with reduced dyskinesias. Progress appears to be stepwise, starting ...Continue Reading

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Citations

Jun 22, 2006·Neurotoxicity Research·M F BealT Archer
Aug 12, 2005·Neurorehabilitation and Neural Repair·W-L Kuan, R A Barker
Oct 16, 2007·Journal of the Neurological Sciences·R Laguna GoyaR A Barker
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Lawrence K Low, Hwai-Jong Cheng
May 16, 2015·The Journal of Comparative Neurology·Rafer Willenberg, Oswald Steward

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