PMID: 720074Oct 1, 1978Paper

Clinical experience with implant contraception

Contraception
E M Coutinho

Abstract

Subdermal implants of polysiloxane (Silastic) capsules containing a number of synthetic progestagens have been studied in clinical trials to determine their contraceptive effectiveness and acceptability. The steroids studied include norgestrienone (R2010), gestrigone (R2323), megestrol acetate, d-norgestrel, norethindrone, ST-1435, lynestrenol and R-1364. With some of these steroids, studies have been undertaken with a varying number of implanted capsules. The estimated duration of use varies from 6 months to 6 years depending on dose and release rate of the individual steroid. The results of these studies involving about 5000 women in 8 years, indicate in general a high rate of effectiveness, as well as acceptability. Continuation rates at one year were generally 80% or greater. Abnormal bleeding patterns are the major disadvantage. Studies with implatns containing a combination of estrogen and progestogen are being undertaken in an attempt to improve the bleeding pattern.

Citations

Dec 1, 1995·Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception·I BarbosaU Ulmsten
Feb 28, 2002·Contraception·I Sivin, Alfred Moo-Young
Aug 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M Cooper
May 1, 1989·American Journal of Obstetrics and Gynecology·D Shoupe, D R Mishell
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Jan 12, 2017·Ciência & saúde coletiva·Ana Cristina de Lima PimentelLuiz Antonio da Silva Teixeira
Jan 16, 2014·Hand : Official Journal of the American Association for Hand Surgery·Joshua M Adkinson, Jay S Talsania
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