Clinical experience with local excision and postoperative radiation therapy for rectal cancer

Diseases of the Colon and Rectum
B D Minsky

Abstract

The standard surgical treatment for patients with potentially curable transmural and/or node-positive rectal cancer is a low anterior resection or abdominoperineal resection. There is increasing interest in the use of local excision and postoperative radiation therapy as primary therapy for selected rectal cancers. The limited data suggest that the approach of local excision and postoperative radiation therapy should be limited to patients with either T1 tumors with adverse pathologic factors or T2 tumors. Transmural tumors have a 24 percent local failure rate and are treated more effectively with standard surgery and preoperative or postoperative therapy. The results of local excision and postoperative radiation therapy are encouraging; however, more experience is needed to determine whether this approach ultimately has local control and survival rates similar to standard surgery.

References

Mar 14, 1991·The New England Journal of Medicine·J E KrookJ A Mailliard
Jun 1, 1991·Archives of Surgery·G SteeleJ M Jessup
Aug 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G WillettC C Compton
Jun 6, 1985·The New England Journal of Medicine·UNKNOWN Gastrointestinal Tumor Study Group
May 1, 1987·Archives of Surgery·J C NelsonN R Thomford
Nov 13, 1986·The New England Journal of Medicine·H O DouglassUNKNOWN Gastrointestinal Tumor Study Group
Feb 1, 1984·Diseases of the Colon and Rectum·M GriggE S Hughes
Apr 1, 1980·American Journal of Surgery·J S Abrams
Jun 15, 1980·Cancer·A M CohenM Shinnar

❮ Previous
Next ❯

Citations

Aug 19, 2000·Diseases of the Colon and Rectum·A MellgrenJ García-Aguilar
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J P GerardJ C Thalabard
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J P GérardJ C Souquet
Jun 27, 2001·American Journal of Surgery·T MasakiT Muto
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·A AumockR J Myerson
Dec 17, 2009·Clinics in Colon and Rectal Surgery·John Touzios, Kirk A Ludwig
Oct 7, 2003·American Journal of Clinical Oncology·Sophie LavertuJames A Martenson
Mar 13, 2013·Diseases of the Colon and Rectum·Calvin F JohnstonNancy N Baxter
Jan 1, 1995·Cancer Investigation·P L Baron, E R Sigurdson
Sep 24, 2005·Journal of Surgical Oncology·Tadahiko MasakiYutaka Atomi
Apr 9, 2005·Surgical Oncology Clinics of North America·Anders MellgrenDavid A Rothenberger
Jun 7, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Imran HassanJames W Fleshman
Feb 16, 2018·International Journal of Colorectal Disease·Sun Min ParkIn Kyu Lee
Apr 4, 2006·Journal of Evaluation in Clinical Practice·Amanda Welch, Pamela Dawson
Jan 6, 2007·Scandinavian Journal of Occupational Therapy·A Birgitta GunnarssonMona Eklund
Sep 8, 1998·Seminars in Surgical Oncology·D G Kim, R D Madoff
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L K TempleR S McLeod

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.