Clinical experience with the inactivated hepatitis A vaccine, Avaxim 80U Pediatric

Expert Review of Vaccines
Catherine BravoYaël Thollot

Abstract

Hepatitis A, caused by hepatitis A virus (HAV), is primarily transmitted via the fecal/oral route either through ingestion of contaminated food and water or through direct contact with an infectious person. Prevalence of hepatitis A is strongly correlated with socioeconomic factors, decreasing with increased socio-economic development, access to clean water and sanitation. Vaccination against HAV should be part of a comprehensive plan for the prevention and control of viral hepatitis, either as part of regular childhood immunization programs or with other recommended vaccines for travelers. Areas covered: We present here evidence for the immunogenicity and safety of an inactivated HAV pediatric vaccine (Avaxim® 80U Pediatric, Sanofi Pasteur), indicated for use in children aged 12 months to 15 years. Data evaluated are from trials undertaken during the clinical development of this vaccine, a systematic literature review and post-market pharmacovigilance. Expert opinion: The pediatric HAV vaccine is highly immunogenic and generates long-lasting protection against hepatitis A disease in children. The safety and immunogenicity data presented in this review suggest that the pediatric HAV vaccine is a valuable option in the preventio...Continue Reading

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Citations

Apr 26, 2020·Journal of the Pediatric Infectious Diseases Society·Luis Furuya-KanamoriColleen L Lau
Jan 23, 2021·Biomedicines·Claudia FerlitoRaffaele D'Amelio
Aug 26, 2021·Revista brasileira de enfermagem·Alanna Michella Oliveira de Albuquerque da SilvaDiane Fernandes Dos Santos

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