Clinical experience with transcutaneous supraorbital nerve stimulation in patients with refractory migraine or with migraine and intolerance to topiramate: a prospective exploratory clinical study

BMC Neurology
Michail VikelisEvaggelia Kararizou

Abstract

Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation, including the Cefaly® device, for the treatment of various types of pain is a relatively new field of interest. The aim of the present study was to explore the clinical experience with Cefaly® in a cohort of migraine patients previously refractory or intolerant to topiramate prophylaxis. A prospective, multi-center clinical study was performed in patients diagnosed with episodic or chronic migraine with a previous failure to topiramate treatment requiring prevention with Cefaly® according to the treating physician's suggestion. A 1-month period of baseline observation was followed by a 3-month period of observation during the use of transcutaneous supraorbital nerve stimulation (t-SNS) with Cefaly® as the only preventive treatment. A small but statistically significant decline was shown over time in the number of days with headache (HA), the number of days with HA with intensity ≥5/10, and the number of days with use of acute medication after 3 months (p < 0.001 for all of the three changes). Twenty-three patients (65.7%) expressed their satisfaction and intent to continue treatment with Cefaly®. C...Continue Reading

References

Aug 1, 1984·Annals of Neurology·M A Moskowitz
Apr 29, 2006·Headache·Shahram N MalikStephen D Silberstein
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuR S Taylor
Feb 4, 2012·Pain Practice : the Official Journal of World Institute of Pain·Ariel BergerGerry Oster
Jun 19, 2013·Cephalalgia : an International Journal of Headache·UNKNOWN Headache Classification Committee of the International Headache Society (IHS)
Aug 15, 2014·Cephalalgia : an International Journal of Headache·Wim M MullenersMattias Linde

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Citations

Jun 16, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Michail VikelisAlan M Rapoport
Jun 14, 2018·Expert Review of Neurotherapeutics·Jean Schoenen, Gianluca Coppola
Oct 7, 2018·Acta Neurologica Scandinavica·Vlasta Vukovic Cvetkovic, Rigmor H Jensen
May 28, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Carlos M OrdásJavier Pardo-Moreno
Nov 20, 2018·Cephalalgia : an International Journal of Headache·Denise E ChouJean Schoenen
May 16, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G R Tabeeva
Oct 21, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Heiko PohlLars Michels
Jul 29, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·R BelvísJ M Láinez
May 29, 2021·Continuum : Lifelong Learning in Neurology·Rebecca Burch
May 21, 2021·Pain Practice : the Official Journal of World Institute of Pain·Flávia S DominguesGuilherme A M de Barros
Jun 22, 2021·Anesthesiology and Pain Medicine·Ivan UritsOmar Viswanath

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