PMID: 2484676Jan 1, 1986Paper

Clinical experiences in the treatment of neuroblastoma with 131I-metaiodobenzylguanidine

Pediatric Hematology and Oncology
J TreunerW Kaiser

Abstract

Treatment of neuroblastoma is an unsolved problem of pediatric oncology. In spite of highly intensified chemotherapy, the long-term survival rate of children with a metastatic neuroblastoma is below 10%. We therefore used 131I-metaiodobenzylguanidine (MIBG) for the first time to treat children with a neuroblastoma in relapse or primary unresponsiveness to chemotherapy. We had previously demonstrated that MIBG is useful for the scintigraphic imaging of neuroblastoma lesions and had investigated the cytotoxicity and uptake of MIBG in various neuroblastoma cell lines. We treated 6 children with neuroblastoma in a total of 19 courses. Three of the children suffered from a relapse of neuroblastoma; 3 had never gained a remission. Four of the 6 children lost their bone pain and fever during the first 3 days. In 5 of the 6 children the solid tumor as well as the bone marrow infiltration responded to MIBG treatment, with responses ranging from transitory decrease of the tumor mass to complete disappearance of abdominal tumors. We also witnessed a stabilization of osteolytic lesions, a decrease in elevated serum catecholamines, and a decrease in bone marrow infiltration. Five of the 6 children died of tumor progression 55-249 days after...Continue Reading

References

Feb 1, 1985·Deutsche medizinische Wochenschrift·B KimmigJ Adolph
Jul 2, 1981·The New England Journal of Medicine·J C SissonN W Thompson
Jan 1, 1980·World Journal of Surgery·J L Grosfeld, R L Baehner

❮ Previous
Next ❯

Citations

Nov 3, 2009·Cancer Biotherapy & Radiopharmaceuticals·Ernst J Postema, Alexander J B McEwan
Jan 1, 1990·European Journal of Nuclear Medicine·L TronconeR Mastrangelo
Apr 16, 2015·TheScientificWorldJournal·Daiki Kayano, Seigo Kinuya
Jan 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephan A GruppGregory A Yanik
Nov 9, 2016·Critical Reviews in Oncology/hematology·Roberto LukschGian Paolo Tonini
Dec 18, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jayne S WilsonMark N Gaze
Jul 27, 2018·The British Journal of Radiology·Archi AgrawalNilendu Purandare
Jan 1, 1990·Pediatric Hematology and Oncology·I YanivT Philip
Jan 1, 1992·Calcified Tissue International·S NakamuraM Tamatani
Jun 15, 1990·International Journal of Cancer. Journal International Du Cancer·D GuerreauJ F Chatal
Jan 30, 2018·Japanese Journal of Clinical Oncology·Akira NakagawaraMasanori Nishi
Mar 29, 2020·Annals of Nuclear Medicine·Daiki KayanoSeigo Kinuya
Aug 14, 2018·Nuclear Medicine and Molecular Imaging·Daiki Kayano, Seigo Kinuya
Jan 1, 1987·Medical and Pediatric Oncology·J TreunerD Niethammer
Jun 22, 2012·Journal of Surgical Oncology·Jorge A CarrasquilloClara C Chen
Jun 3, 2020·International Journal of Molecular Sciences·Andrea CiminiOrazio Schillaci
Sep 3, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Neeta Pandit-Taskar, Shakeel Modak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.