Abstract
Immune-mediated thrombotic thrombocytopenic purpura is characterized by severe thrombocytopenia and microangiopathic hemolytic anemia. It is primarily caused by immunoglobin G type autoantibodies against ADAMTS13, a plasma metalloprotease that cleaves von Willebrand factor. However, reliable markers predictive of patient outcomes are yet to be identified. Seventy-three unique patients with a confirmed diagnosis of immune-mediated thrombotic thrombocytopenic purpura between April 2006 and December 2017 were enrolled from the Univeristy of Alabama at Birmingham Medical Center. Clinical information, laboratory values, and a panel of special biomarkers were collected and/or determined. The results demonstrated that the biomarkers associated with endothelial injury (e.g., von Willebrand factor antigen and collagen-binding activity), acute inflammation (e.g., human neutrophil peptides 1-3 and histone/deoxyribonucleic acid complexes), and activation of the complement alternative pathway (e.g., factors Bb and iC3b) were all significantly increased in patients with acute immune-mediated thrombotic thrombocytopenic purpura compared to those in the healthy controls. Moreover, failure to normalize platelet counts within 7 days or failure t...Continue Reading
Citations
Feb 12, 2019·Journal of Thrombosis and Haemostasis : JTH·Jenny K McDanielX Long Zheng
Aug 15, 2019·Blood·Liang ZhengX Long Zheng
Nov 7, 2019·Journal of Thrombosis and Haemostasis : JTH·Paul KnoeblFilip Callewaert
Nov 15, 2019·Journal of Clinical Apheresis·Na ZhaoChangcheng Zheng
Sep 12, 2020·Journal of Thrombosis and Haemostasis : JTH·X Long ZhengFlora Peyvandi
Sep 12, 2020·Journal of Thrombosis and Haemostasis : JTH·X Long ZhengFlora Peyvandi
Sep 12, 2020·Journal of Thrombosis and Haemostasis : JTH·X Long ZhengFlora Peyvandi
Apr 4, 2020·Expert Review of Hematology·Andrés Gómez-De LeónDavid Gómez-Almaguer
Mar 30, 2020·Medicine·Hai-Xu WangLai-Jun Song
May 27, 2020·British Journal of Haematology·Ruo-Yun GuiXiao-Hui Zhang
Apr 1, 2020·Vox Sanguinis·Chong H KimHuy P Pham
Dec 20, 2019·Blood Advances·Jingrui SuiX Long Zheng
Nov 4, 2020·Blood Advances·Ruinan LuX Long Zheng
Nov 15, 2020·Journal of Thrombosis and Haemostasis : JTH·Jingrui SuiX Long Zheng
Jan 19, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Raima MemonX Long Zheng
Jan 19, 2021·La Revue de médecine interne·R PrevelUNKNOWN Centre National de Référence des Microangiopathies Thrombotiques
Apr 28, 2021·Journal of Medical Economics·Laurence PollissardHuy P Pham
May 14, 2021·Thrombosis and Haemostasis·Ruinan Lu, X Long Zheng
Jun 2, 2021·Journal of Thrombosis and Haemostasis : JTH·X Long Zheng
Sep 9, 2021·Blood Advances·Kadri KangroKaren Vanhoorelbeke
Oct 14, 2021·Annals of Hematology·Julio Del Río-GarmaUNKNOWN “Registro Español de la Púrpura Trombocitopénica Trombótica (REPTT)”, and the “Grupo Español de Aféresis (GEA)”
Feb 19, 2021·Cerebrovascular Diseases Extra·Chen LinX Long Zheng