Clinical factors associated with prognosis in low-grade serous ovarian carcinoma: experiences at two large academic institutions in Korea and Taiwan.

Scientific Reports
Jun-Hyeok KangYoo-Young Lee

Abstract

Low-grade ovarian serous carcinoma (LGSOC) has clinical features different from high-grade serous ovarian carcinoma (HGSOC) accounting for the majority of epithelial ovarian cancer. Because of its rarity, previous studies have only focused on the high-grade disease without considering the differences between the two subtypes. This study aimed to evaluate the effect of the clinical prognostic factors known for HGSOC on survival in patients with LGSOC. Based on the Federation of Gynecology and Obstetrics (FIGO) stage, progression-free survival (PFS) was markedly decreased in advanced disease compared with early disease. For stage I, patients with stage IC had poorer survival than those with stage IA and IB regardless of the number of cycles of adjuvant chemotherapy. For advanced disease, no gross residual disease after primary cytoreductive surgery was significantly associated with longer PFS when compared with gross residual disease. In multivariate analysis for PFS and overall survival (OS), age, preoperative CA-125, time interval from surgery to chemotherapy, and the number of cycles of adjuvant chemotherapy were not associated with prognosis. Complete cytoreduction was the only independent prognostic factor for PFS (HR 2.45, ...Continue Reading

References

Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jeffrey D SeidmanBrigitte M Ronnett
Apr 17, 2004·The American Journal of Surgical Pathology·Anais MalpicaElvio G Silva
Jun 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C Blake Gilks
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chih-Yi HsuIe-Ming Shih
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
May 24, 2006·Seminars in Oncology·Robert F Ozols
Aug 2, 2006·Obstetrics and Gynecology·David M GershensonDiane C Bodurka
May 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A SantillanR E Bristow
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William E WinterUNKNOWN Gynecologic Oncology Group Study
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William E WinterUNKNOWN Gynecologic Oncology Group
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Steven C Plaxe
Oct 22, 2008·Current Oncology Reports·Kathleen M Schmeler, David M Gershenson
Apr 22, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Martin KöbelUNKNOWN Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency, Vancouver BC
Aug 31, 2010·The American Journal of Pathology·Kwong-Kwok WongDavid M Gershenson
May 5, 2012·Gynecologic Oncology·Ivan Diaz-PadillaAntonio Gonzalez-Martin
May 28, 2013·Gynecologic Oncology·Ignacio RomeroDavid M Gershenson
May 30, 2013·American Society of Clinical Oncology Educational Book·David M Gershenson
Feb 24, 2015·Gynecologic Oncology·Helen E DinkelspielJason D Wright
Jul 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David M GershensonCharlotte C Sun
Dec 18, 2015·The Cochrane Database of Systematic Reviews·Theresa A LawrieHenry C Kitchener
Jan 1, 2016·JAMA Oncology·Barbara M NorquistMichael J Birrer
May 4, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D M Gershenson
Aug 22, 2017·Gynecologic Oncology·Alexander MelamedJ Alejandro Rauh-Hain
Dec 1, 2017·Journal of Gynecologic Oncology·Koji MatsuoDavid M Gershenson
Mar 27, 2018·PloS One·Lin-Chau ChangWen-Fang Cheng
Aug 22, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yoo-Young LeeTaymaa May
Oct 24, 2018·International Journal of Cancer. Journal International Du Cancer·J FerlayF Bray

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