PMID: 34103436Jun 10, 2021Paper

CLINICAL FACTORS ASSOCIATED WITH THE RISK OF PULMONARY SARCOIDOSIS RELAPSE.

Georgian Medical News
V GavrysyukO Bychenko

Abstract

Long-term outcomes of glucocorticosteroid therapy in pulmonary sarcoidosis patients testify for high rate of relapses, which nowadays are the most acute problem in providing care to these patients. Aim - to study clinical factors, associated with pulmonary sarcoidosis relapse. 108 patients with newly diagnosed pulmonary sarcoidosis were examined (stage II - 102 patients, stage III - 6 patients). There were 48 male and 60 female, age from 24 to 64 years. The diagnosis of sarcoidosis was verified by high-resolution computed tomography (CT). All patients received GCS therapy with methylprednisolone 0,4 mg/kg for 4 weeks with subsequent dose tapering down to 0,1 mg/kg by the end of 6th month. Treatment was continued until clinical cure. Upon discontinuation of therapy the patients were followed for 2 years using CT-control in 6, 12 and 24 months. The relapse of sarcoidosis was registered in 56 patients (group 1); no relapse - in 52 patients (group 2). The rate of relapses was assessed in association with 10 clinical factors. Significance of the differences between qualitative indices was calculated as (M ± m) and Student's t value was calculated. Pearson's chi-squared test and Fisher's exact test were used to analyze the rate of re...Continue Reading

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