Clinical factors influencing the absorption of 125I-NPH insulin in diabetic patients

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
K KølendorfT Deckert

Abstract

Clinical factors which might influence the absorption of subcutaneously injected 125I-NPH insulin were studied in 101 diabetics. The disappearance curve was monoexponential after a delay period of 1.5 +/- 0.8 h (mean +/- SD). Lipohypertrophy significantly prolonged insulin absorption (half life (T1/2) = 11.2 +/- 3.1 h, p = 0.0001). Low bicarbonate levels increased the absorption (T1/2 3.9 +/- 2.3 h, p less than 0.05). Lean diabetics had a faster absorption (6.2 +/- 1.9 h) than normal weight diabetics (7.5 +/- 2.0 h, p less than 0.02). Sex, age, diabetes duration and injection depth did not influence T1/2. The half life was significantly inversely correlated to the resting subcutaneous blood flow (r = 0.882, p less than 0.01). The overall interindividual coefficient of variation for insulin absorption in nonketotic diabetics was 27.4%. Also considerable intra-patient day-to-day variation was found (24.5%), and between different injection sites (30.2%). These variations emphasize the drawbacks of conventional insulin therapy in the management of insulin-requiring diabetics.

Citations

Oct 12, 2010·Diabetes & Metabolism·A FridUNKNOWN Scientific Advisory Board for the Third Injection Technique Workshop
Nov 27, 2002·Diabetes Technology & Therapeutics·Lutz Heinemann
Jul 28, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Shinya AbeToshikazu Yamanouchi
Mar 1, 1995·Journal of General Internal Medicine·R L Schiff, M A Emanuele
Jan 1, 1989·Journal of Toxicology. Clinical Toxicology·M H Samuels, R H Eckel
Jan 18, 2005·IEEE Transactions on Bio-medical Engineering·Malgorzata E WilinskaRoman Hovorka
Jul 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P Hildebrandt, K Birch
Dec 15, 2006·Current Medical Research and Opinion·Gregory E Peterson
Feb 1, 1989·Journal of Pharmacokinetics and Biopharmaceutics·E MosekildeB Thorsteinsson
Feb 4, 2011·Organogenesis·Justin M Gregory, Daniel J Moore
Apr 28, 2004·Diabetes Care·Philip HomeUNKNOWN Study to Evaluate the Administration of Detemir Insulin Efficacy, Safety and Suitability (STEADINESS) Study Group
Sep 7, 2016·Mayo Clinic Proceedings·Anders H FridKenneth W Strauss
Nov 1, 1990·The Diabetes Educator·C ZehrerJ Bantle
Jun 2, 2010·Journal of Diabetes Science and Technology·Lutz Heinemann
Aug 31, 2014·Journal of Diabetes Science and Technology·Lutz HeinemannRoman Hovorka
Mar 12, 2015·Journal of Diabetes Science and Technology·Dayu LvMarc D Breton
Dec 3, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J-L ArdilouzeB A Fielding
Jul 18, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K KølendorfS R Heller
Mar 27, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·T R PieberL I Robertson
Apr 9, 1999·Acta Paediatrica. Supplement·K Dahl-Jørgensen
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·F H ZielC S Rosenberg
Oct 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·A PetersW Kerner
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·J C ThowP D Home
May 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·R J HeineE A van der Veen
Jan 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·J KastrupH H Parving
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·P H de MeijerA van't Laar
Oct 19, 2001·Clinical Pharmacokinetics·A Lindholm, L V Jacobsen
May 1, 1992·The Diabetes Educator·A M Albisser, M Sperlich
Jan 12, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·R M BrackenS C Bain
Oct 13, 2012·Physics in Medicine and Biology·M ThomsenF Pfeiffer
Nov 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·J C ThowP D Home
Jan 19, 2017·Diabetes Technology & Therapeutics·Linong JiLaurence J Hirsch
Jun 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·J E HenriksenH Beck-Nielsen
Sep 1, 2007·Expert Review of Endocrinology & Metabolism·Jens Sandahl Christiansen
Jun 11, 2003·Diabetes, Obesity & Metabolism·Jian-Wen ChenTorsten Lauritzen

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