Clinical factors to predict outcome following mogamulizumab in adult T-cell leukemia-lymphoma

International Journal of Hematology
Jun NakashimaYasushi Miyazaki

Abstract

Adult T-cell leukemia-lymphoma (ATL) is a distinct T-cell malignancy caused by human T-cell leukemia virus type-1; the prognosis is very poor. Mogamulizumab (Moga), an antibody drug for CC chemokine receptor type 4, has been introduced for the treatment of ATL. However, the prognosis of relapsed or refractory ATL remains poor and the characteristics of patients who derive clinical benefit from treatment with Moga remain poorly understood. We analyzed the associations of clinical factors with the outcome after Moga treatment. Forty-five patients treated with Moga monotherapy were evaluated. The median age of the patients was 69 years, and 40% were female. The median overall survival (OS) time was 17.6 months and the 2-year OS rate was 43.2%. Number of prior therapies and response to prior therapy were predictive clinical features in univariate analysis for OS. Performance status, corrected serum calcium level, serum lactate dehydrogenase level, Japan Clinical Oncology Group-prognostic index (PI), and simplified ATL-PI at Moga treatment were also associated with the prognosis after Moga monotherapy. Improved understanding of the clinical factors predicting the prognosis after Moga may contribute to improved treatment strategies f...Continue Reading

References

Mar 12, 2003·International Journal of Hematology·Kunihiro TsukasakiUNKNOWN Lymphoma Study Group of the Japan Clinical Oncology Group
Oct 31, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kunihiro TsukasakiUNKNOWN Japan Clinical Oncology Group Study JCOG9801
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi IshidaRyuzo Ueda
Apr 5, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hiroo KatsuyaKazuo Tamura
Sep 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takashi IshidaTomoko Ohtsu
Oct 12, 2016·Clinical Lymphoma, Myeloma & Leukemia·Satoshi IyamaMitsutoshi Kurosawa
Feb 6, 2017·European Journal of Haematology·Masaaki SekineKazuya Shimoda

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Citations

Feb 12, 2019·European Journal of Haematology·Kenji IshitsukaKensei Tobinai
Aug 31, 2019·International Journal of Hematology·Yuma SakamotoHiroshi Inagaki
Mar 5, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jamal Majidpoor, Keywan Mortezaee

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