Clinical feasibility of early scanning after administration of 68 Ga-DOTATOC

Annals of Nuclear Medicine
Yuji NakamotoKaori Togashi

Abstract

Positron emission tomography (PET)/computed tomography (CT) using 68Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-D-Phe1-Tyr3-octreotide (DOTATOC) is usually performed about 1-h post-injection; however, because of rapid blood clearance, the waiting time for scanning could possibly be shortened without affecting diagnostic performance. The purpose of this study was to investigate the feasibility of early scanning at 30 min post-injection. Thirty-eight patients who underwent DOTATOC-PET/CT were analyzed. After administration of 68Ga-DOTATOC, data acquisition was performed twice, at 30-min and 60-min post-injection. The number of known or suspected pathological lesions, and quantitative values of those lesions and physiological uptake were compared. SUVmax, SUVpeak, metabolic tumor volume (MTV), and total lesion uptake (TLU) were calculated as quantitative values of the pathological lesions. A total of 125 known or suspected pathological lesions were found at both timepoints, with no differences between the two datasets. The SUVmax, SUVpeak, MTV, and TLU were highly reproducible, with Spearman's ρ of 0.983, 0.986, 0.918, and 0.981, respectively. The average percent differences (%DIFFave) defined as the diff...Continue Reading

References

Aug 19, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Albert DirisamerWerner Langsteger
Jul 3, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Irene VirgoliniArturo Chiti
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Daniel PutzerIrene Johanna Virgolini
Jan 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Irina VelikyanBarbro Eriksson
Jan 14, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Martin BarrioWolfgang P Fendler
May 27, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Murat Fani BozkurtStefano Fanti

❮ Previous
Next ❯

Citations

Nov 2, 2019·Annals of Nuclear Medicine·Yasuhito Sasaki
Mar 5, 2019·Nuclear Medicine and Molecular Imaging·Seigo Kinuya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.