Clinical Feasibility of Simultaneous Acquisition Rest (99m)Tc/Stress (201)Tl Dual-Isotope Myocardial Perfusion Single-Photon Emission Computed Tomography With Semiconductor Camera

Circulation Journal : Official Journal of the Japanese Circulation Society
Ayano MakitaAtsushi Hirayama

Abstract

The aim of this study was to evaluate the clinical feasibility of simultaneous acquisition of rest (99m)Tc-tetrofosmin/stress (201)Tl dual-isotope single-photon emission computed tomography with a semiconductor gamma camera. Ninety-four patients with known or suspected coronary artery disease (CAD) were enrolled in the study. First, patients were injected with (99m)Tc-tetrofosmin (296 MBq) for rest imaging, followed by (201)Tl (74 MBq) injection during 6 min of vasodilator stress test. Immediately after the stress test, the patients underwent the first electrocardiogram (ECG)-gated simultaneous acquisition including rest and stress perfusion scans. Patients were brought back for the second simultaneous acquisition for the comparison of ECG-gated wall motion between stress and rest scan 30 min later. Coronary angiography was performed in all the patients within 3 months of this protocol. Sensitivity, specificity and accuracy on a per patient basis to detect significant coronary artery stenosis (≥75%) were 88.6%, 79.2% and 86.2%, respectively. Per coronary vessel, sensitivity, specificity and accuracy were as follows: 84.9%, 80.5% and 83% in the left anterior descending coronary artery; 75%, 93.1% and 86.2% in the left circumflex...Continue Reading

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Citations

May 7, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Kenya Kusunose, Hirotsugu Yamada
Jan 5, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Koichi OkudaSeigo Kinuya
May 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Valeria CantoniAlberto Cuocolo
Jul 1, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tali Sharir, Piotr Slomka
Nov 28, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Bernard SongyDuc Nguyen
May 18, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Laetitia ImbertPierre-Yves Marie
Feb 19, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Masakazu YamagishiUNKNOWN Japanese Circulation Society Working Group
Jun 22, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Itta KawamuraHitoshi Matsuo

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