Clinical Feasibility of Single-Source Dual-spiral 4D Dual-Energy CT for Proton Treatment Planning Within the Thoracic Region

International Journal of Radiation Oncology, Biology, Physics
Patrick WohlfahrtAnnika Jakobi

Abstract

Single-source dual-spiral dual-energy computed tomography (DECT) provides additional patient information but is prone to motion between the 2 consecutively acquired computed tomography (CT) scans. Here, the clinical applicability of dual-spiral time-resolved DECT (4D-DECT) for proton treatment planning within the thoracic region was evaluated. Dual-spiral 4D-DECT scans of 3 patients with lung cancer were acquired. For time-averaged datasets and 4 breathing phases, the geometric conformity of 80 kVp and 140 kVp 4D-DECT scans before image post-processing was assessed by normalized cross correlation (NCC). Additionally, the conformity of the corresponding DECT-derived 58 keV and 79 keV pseudo-monoenergetic CT datasets after image post-processing, including deformable image registration (DIR), was determined. To analyze the reliability of proton dose calculation, clinical (PlanClin) and artificial worst-case (PlanWorstCase, targeting the diaphragm) treatment plans were calculated on 140 kVp and 79 keV datasets and compared with gamma analyses (0.1% dose-difference and 1 mm distance-to-agreement criterion). The applicability of a patient-specific DECT-based prediction of stopping-power ratio (SPR) was investigated and proton range s...Continue Reading

Citations

Oct 24, 2019·The British Journal of Radiology·Patrick Wohlfahrt, Christian Richter
Mar 28, 2020·Medical Physics·Cynthia H McColloughNorbert J Pelc
May 28, 2020·Physics in Medicine and Biology·Felicia Fibiani PermatasariArmin Lühr
Sep 29, 2020·Frontiers in Oncology·George NoidX Allen Li
Dec 5, 2020·International Journal of Particle Therapy·Sina MossahebiJerimy C Polf
Jul 31, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nils PetersChristian Richter
Nov 15, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nils PetersChristian Richter

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